Recombination-dependent mutation in non-dividing cells

Susan M. Rosenberg; Reuben S. Harris; Simonne Longerich; Anne M. Galloway

doi:10.1016/0027-5107(95)00092-5

Recombination-dependent mutation in non-dividing cells

Susan M. Rosenberg, Reuben S. Harris, Simonne Longerich, Anne M. Galloway

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.

Original language	English (US)
Pages (from-to)	69-76
Number of pages	8
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	350
Issue number	1
DOIs	https://doi.org/10.1016/0027-5107(95)00092-5
State	Published - Feb 19 1996
Externally published	Yes

Keywords

Adaptive mutation
DNA double-strand break
Directed mutation
Escherichia coli
Mismatch repair
RecA
RecBCD
Recombination
Repent instability

ASJC Scopus subject areas

Genetics
Molecular Biology
Health, Toxicology and Mutagenesis

Access to Document

10.1016/0027-5107(95)00092-5

Cite this

@article{328d877987134554b8bee750f041a260,

title = "Recombination-dependent mutation in non-dividing cells",

abstract = "Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.",

keywords = "Adaptive mutation, DNA double-strand break, Directed mutation, Escherichia coli, Mismatch repair, RecA, RecBCD, Recombination, Repent instability",

author = "Rosenberg, {Susan M.} and Harris, {Reuben S.} and Simonne Longerich and Galloway, {Anne M.}",

note = "Funding Information: We thank G. Haljan, P.J. Hastings and H. Razavy for commentso n the manuscript.S upportedb y grants from Natural Sciences and Engineering Research Council of Canada (NSERC), Medical Research Council of Canada. and the Alberta Heritage Foundation for Medical Research (AHFMR). an AHFMR graduate studentship, NSERC graduate studentship, Walter H. Johns graduate studentship and Lionel McLeod fellowship to RSH. and an AHFMR postdoctoral fellowship to AMG. SMR is an Alberta Heritage Medical Scholar.",

year = "1996",

month = feb,

day = "19",

doi = "10.1016/0027-5107(95)00092-5",

language = "English (US)",

volume = "350",

pages = "69--76",

journal = "Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis",

issn = "0027-5107",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Recombination-dependent mutation in non-dividing cells

AU - Rosenberg, Susan M.

AU - Harris, Reuben S.

AU - Longerich, Simonne

AU - Galloway, Anne M.

N1 - Funding Information: We thank G. Haljan, P.J. Hastings and H. Razavy for commentso n the manuscript.S upportedb y grants from Natural Sciences and Engineering Research Council of Canada (NSERC), Medical Research Council of Canada. and the Alberta Heritage Foundation for Medical Research (AHFMR). an AHFMR graduate studentship, NSERC graduate studentship, Walter H. Johns graduate studentship and Lionel McLeod fellowship to RSH. and an AHFMR postdoctoral fellowship to AMG. SMR is an Alberta Heritage Medical Scholar.

PY - 1996/2/19

Y1 - 1996/2/19

N2 - Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.

AB - Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.

KW - Adaptive mutation

KW - DNA double-strand break

KW - Directed mutation

KW - Escherichia coli

KW - Mismatch repair

KW - RecA

KW - RecBCD

KW - Recombination

KW - Repent instability

UR - http://www.scopus.com/inward/record.url?scp=0030070432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030070432&partnerID=8YFLogxK

U2 - 10.1016/0027-5107(95)00092-5

DO - 10.1016/0027-5107(95)00092-5

M3 - Article

C2 - 8657199

AN - SCOPUS:0030070432

SN - 0027-5107

VL - 350

SP - 69

EP - 76

JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

IS - 1

ER -

Recombination-dependent mutation in non-dividing cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this