Recombination-dependent mutation in non-dividing cells

Susan M. Rosenberg, Reuben S. Harris, Simonne Longerich, Anne M. Galloway

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.

Original languageEnglish (US)
Pages (from-to)69-76
Number of pages8
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume350
Issue number1
DOIs
StatePublished - Feb 19 1996
Externally publishedYes

Keywords

  • Adaptive mutation
  • Directed mutation
  • DNA double-strand break
  • Escherichia coli
  • Mismatch repair
  • RecA
  • RecBCD
  • Recombination
  • Repent instability

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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