Reciprocal transfer of abnormalities in clonable B lymphocytes and myeloid progenitors between NZB and DBA/2 mice

H. Jyonouchi, P. W. Kincade, R. A. Good, G. Fernandes

Research output: Contribution to journalArticle

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Abstract

Previous studies in this laboratory revealed that NZB mice have abnormalities of myeloid progenitor populations from an early age such that they are poorly responsive to a particular type of colony-stimulating activity (CSA). In addition, these mice develop abnormally high numbers of B cells that can be cloned in semisolid agar cultures and that are atypical in resisting inhibition by anti-μ antibodies. To investigate whether these abnormalities, like other autoimmune phenomena studied previously, are transferrable with hemopoietic cell grafts, we performed reciprocal bone marrow transplants between NZB and normal DBA/2 mice. Irradiated control mice given syngeneic marrow did not change with respect to any of the parameters that were measured. In contrast, DBA/2 recipients of NZB marrow were indistinguishable from NZB mice in terms of CSA responses and incidences of anti-μ resistant B cells. The proportions but not total numbers of clonable B cells were elevated in these mice until at least 16 wk after grafting. Conversely, NZB mice given DBA/2 cells had all of the normal characteristics of DBA/2 mice. Transplantation did not cause significant changes in hematocrits, reticulocyte counts, or spleen weights. Therefore, all elements necessary for expression of these lymphoid and nonlymphoid abnormalities of NZB mice are intrinsic to radiosensitive hemopoietic cells.

Original languageEnglish (US)
Pages (from-to)1232-1235
Number of pages4
JournalJournal of Immunology
Volume127
Issue number3
StatePublished - 1981
Externally publishedYes

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Inbred NZB Mouse
Inbred DBA Mouse
B-Lymphoid Precursor Cells
B-Lymphocytes
Bone Marrow
Reticulocyte Count
Transplants
Hematocrit
Agar
Anti-Idiotypic Antibodies
Spleen
Transplantation
Weights and Measures
Incidence
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Jyonouchi, H., Kincade, P. W., Good, R. A., & Fernandes, G. (1981). Reciprocal transfer of abnormalities in clonable B lymphocytes and myeloid progenitors between NZB and DBA/2 mice. Journal of Immunology, 127(3), 1232-1235.

Reciprocal transfer of abnormalities in clonable B lymphocytes and myeloid progenitors between NZB and DBA/2 mice. / Jyonouchi, H.; Kincade, P. W.; Good, R. A.; Fernandes, G.

In: Journal of Immunology, Vol. 127, No. 3, 1981, p. 1232-1235.

Research output: Contribution to journalArticle

Jyonouchi, H, Kincade, PW, Good, RA & Fernandes, G 1981, 'Reciprocal transfer of abnormalities in clonable B lymphocytes and myeloid progenitors between NZB and DBA/2 mice', Journal of Immunology, vol. 127, no. 3, pp. 1232-1235.
Jyonouchi, H. ; Kincade, P. W. ; Good, R. A. ; Fernandes, G. / Reciprocal transfer of abnormalities in clonable B lymphocytes and myeloid progenitors between NZB and DBA/2 mice. In: Journal of Immunology. 1981 ; Vol. 127, No. 3. pp. 1232-1235.
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