Recent developments in antimicrobial therapy for gastrointestinal infections

Travis J. Carlson, Anne J. Gonzales-Luna, Kevin W. Garey

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Purpose of reviewThis focused, narrative review summarizes human clinical trial data for direct-acting antimicrobials in development for the treatment of gastrointestinal infections that were published in the past 18 months (1 January 2019 to 30 June 2020).Recent findingsAntimicrobial agents for Clostridioides difficile infection (n = 6), cryptosporidiosis (n = 1), cytomegalovirus infection (n = 3) and Helicobacter pylori infection (n = 1) have completed and/or are undergoing human clinical trials.SummaryAlthough this review highlights significant advances in four disease states, many common gastrointestinal pathogens have no antimicrobials in human clinical trials, emphasizing the need for continued prioritization in this field of study.

Original languageEnglish (US)
Pages (from-to)30-36
Number of pages7
JournalCurrent Opinion in Gastroenterology
Issue number1
StatePublished - Jan 1 2021
Externally publishedYes


  • Clostridioides difficile
  • Clostridium difficile
  • cryptosporidium
  • cytomegalovirus
  • diarrhea
  • gastroenteritis
  • gastrointestinal infections
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology


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