Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects

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Abstract

The increasing epidemic of obesity and its comorbidities has spurred research interest in adipose biology and its regulatory functions. Recent studies have revealed that the mechanistic target of rapamycin (mTOR) signaling pathway has a critical role in the regulation of adipose tissue function, including adipogenesis, lipid metabolism, thermogenesis, and adipokine synthesis and/or secretion. Given the importance of mTOR signaling in controlling energy homeostasis, it is not unexpected that deregulated mTOR signaling is associated with obesity and related metabolic disorders. In this review, we highlight current advances in understanding the roles of the mTOR signaling pathway in adipose tissue. We also provide a more nuanced view of how the mTOR signaling pathway regulates adipose tissue biology and function. Finally, we describe approaches to modulate the activity and tissue-specific function of mTOR that may pave the way towards counteracting obesity and related metabolic diseases. Adipose tissue is a multifunctional organ displaying enormous plasticity by altering tissue size as well as phenotypic and metabolic functions in response to environmental signals.The mTOR signaling pathway regulates adipose biology and function, including adipogenesis, lipid metabolism, thermogenesis, and adipokine synthesis and/or secretion.Deregulated mTOR signaling is associated with obesity and related metabolic disorders, and strategies of appropriate modulation of the activity and tissue-specific function of mTOR signaling pave the way towards counteracting obesity and its comorbidities.

Original languageEnglish (US)
JournalTrends in Pharmacological Sciences
DOIs
StateAccepted/In press - 2015

Fingerprint

Sirolimus
Tissue
Obesity
Adipose Tissue
Adipogenesis
Adipokines
Therapeutics
Thermogenesis
Lipid Metabolism
Comorbidity
Metabolic Diseases
Plasticity
Homeostasis
Modulation
Research

Keywords

  • Adipogenesis
  • Adipokine
  • Lipid metabolism
  • The mechanistic target of rapamycin (mTOR)
  • Thermogenesis

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

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abstract = "The increasing epidemic of obesity and its comorbidities has spurred research interest in adipose biology and its regulatory functions. Recent studies have revealed that the mechanistic target of rapamycin (mTOR) signaling pathway has a critical role in the regulation of adipose tissue function, including adipogenesis, lipid metabolism, thermogenesis, and adipokine synthesis and/or secretion. Given the importance of mTOR signaling in controlling energy homeostasis, it is not unexpected that deregulated mTOR signaling is associated with obesity and related metabolic disorders. In this review, we highlight current advances in understanding the roles of the mTOR signaling pathway in adipose tissue. We also provide a more nuanced view of how the mTOR signaling pathway regulates adipose tissue biology and function. Finally, we describe approaches to modulate the activity and tissue-specific function of mTOR that may pave the way towards counteracting obesity and related metabolic diseases. Adipose tissue is a multifunctional organ displaying enormous plasticity by altering tissue size as well as phenotypic and metabolic functions in response to environmental signals.The mTOR signaling pathway regulates adipose biology and function, including adipogenesis, lipid metabolism, thermogenesis, and adipokine synthesis and/or secretion.Deregulated mTOR signaling is associated with obesity and related metabolic disorders, and strategies of appropriate modulation of the activity and tissue-specific function of mTOR signaling pave the way towards counteracting obesity and its comorbidities.",
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author = "Huan Cai and Dong, {Lily Q} and Feng Liu",
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AB - The increasing epidemic of obesity and its comorbidities has spurred research interest in adipose biology and its regulatory functions. Recent studies have revealed that the mechanistic target of rapamycin (mTOR) signaling pathway has a critical role in the regulation of adipose tissue function, including adipogenesis, lipid metabolism, thermogenesis, and adipokine synthesis and/or secretion. Given the importance of mTOR signaling in controlling energy homeostasis, it is not unexpected that deregulated mTOR signaling is associated with obesity and related metabolic disorders. In this review, we highlight current advances in understanding the roles of the mTOR signaling pathway in adipose tissue. We also provide a more nuanced view of how the mTOR signaling pathway regulates adipose tissue biology and function. Finally, we describe approaches to modulate the activity and tissue-specific function of mTOR that may pave the way towards counteracting obesity and related metabolic diseases. Adipose tissue is a multifunctional organ displaying enormous plasticity by altering tissue size as well as phenotypic and metabolic functions in response to environmental signals.The mTOR signaling pathway regulates adipose biology and function, including adipogenesis, lipid metabolism, thermogenesis, and adipokine synthesis and/or secretion.Deregulated mTOR signaling is associated with obesity and related metabolic disorders, and strategies of appropriate modulation of the activity and tissue-specific function of mTOR signaling pave the way towards counteracting obesity and its comorbidities.

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