Recanalization of thrombosed superficial femoral arteries with a hydraulic thrombectomy catheter in a canine model

Zhong Qian, Michael Wholey, Hector Ferral, Manuel Maynar, Darren Postoak, John Hamide, William P. Newman, Rogelio Moncada, Arturo Gonzalez-Roman, Carlos Gimenez, Wilfrido R. Castañeda

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

OBJECTIVE. This experiment was conducted to evaluate efficacy and safety of the Oasis thrombectomy catheter on arterial thrombosis in dogs. MATERIALS AND METHODS. Thrombosis was induced in 18 femoral arteries of nine mongrel dogs. Recanalization of the thrombosed femoral artery was performed using a thrombectomy catheter 7-10 days after thrombus induction. Pre- and postprocedural arterial status was documented by angiography. After mechanical thrombectomy, the animals were sacrificed and the femoral arteries were harvested and examined macro- and microscopically. Additionally, in vitro fragmentation was carded out to determine particle size and distribution from the recovered effluent. RESULTS. Subacute thrombosis was successfully created in 15 femoral arteries. Full recanalization was achieved in 80% (12/15) of the thrombosed femoral arteries without any residual thrombus. No significant downstream embolization was documented angiographically. Endothelial denudation was observed in all the treated arteries along with occasional disruption of the internal elastic lamina. No medial injury was seen. Ninety-eight percent of thrombus was liquefied, defined as particles smaller than 15 μm, by the catheter. Particles larger than 400 μm represented 0.27% of the original clot weight. CONCLUSION. Occluded femoral arteries with 7- to 10-day-old thrombus can be efficiently recanalized with the Oasis catheter in dogs without any significant complication. This thrombectomy catheter appears to be highly effective and safe and requires no sophisticated equipment. Blood loss was our major concern regarding use of this catheter but can be minimized by strictly controlling activation time and restricting the inflow into the vascular segment being treated.

Original languageEnglish (US)
Pages (from-to)1557-1563
Number of pages7
JournalAmerican Journal of Roentgenology
Volume173
Issue number6
DOIs
StatePublished - Dec 1999

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Recanalization of thrombosed superficial femoral arteries with a hydraulic thrombectomy catheter in a canine model'. Together they form a unique fingerprint.

Cite this