Recanalization of arterial occlusions with a lensed fiber and a holmium:YAG laser

Christopher J. White; Stephen R. Ramee; Tyrone J. Collins; Juan E. Mesa; Daniel B. Paulsen; Joseph P. Murgo

doi:10.1002/lsm.1900110308

Recanalization of arterial occlusions with a lensed fiber and a holmium:YAG laser

Christopher J. White, Stephen R. Ramee, Tyrone J. Collins, Juan E. Mesa, Daniel B. Paulsen, Joseph P. Murgo

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Laser recanalization of totally occluded swine iliac arteries was performed to assess the safety and efficacy of a lensed fiber laser angioplasty system with a holmium:YAG (2.1 μm) laser. Silica lenses of 1.0 mm, 1.3 mm, and 1.5 mm in diameter attached to the distal end of a 300‐μm diameter silica fiber delivered fluences of 79.5 J/cm², 31.4 J/cm², and 25.5 J/cm², respectively. The pulse duration of the laser was 250 μsec and the repetition rate was 4 Hz. The mean length of the total occlusions was 5.3 ± 2.0 cm (range 0.5 cm to 8.0 cm). Successful recanalization was obtained in 16/16 lesions without angiographic vessel perforation. Angiographically significant residual stenoses (>50%)remained in every case following successful laser recanalization. Histologically there was minimal evidence of thermal or acoustic tissue injury; however, in 4 of 16 arteries there was evidence of deep arterial dissection following laser recanalization. We conclude that this lensed fiber coupled with a holmium:YAG laser is a safe and effective method for crossing total occlusions in the relatively straight iliac arteries of this animal model.

Original language	English (US)
Pages (from-to)	250-256
Number of pages	7
Journal	Lasers in Surgery and Medicine
Volume	11
Issue number	3
DOIs	https://doi.org/10.1002/lsm.1900110308
State	Published - 1991
Externally published	Yes

Keywords

atherosclerotic swine model
laser angioplasty
silica lenses

ASJC Scopus subject areas

Surgery
Dermatology

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10.1002/lsm.1900110308

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title = "Recanalization of arterial occlusions with a lensed fiber and a holmium:YAG laser",

abstract = "Laser recanalization of totally occluded swine iliac arteries was performed to assess the safety and efficacy of a lensed fiber laser angioplasty system with a holmium:YAG (2.1 μm) laser. Silica lenses of 1.0 mm, 1.3 mm, and 1.5 mm in diameter attached to the distal end of a 300‐μm diameter silica fiber delivered fluences of 79.5 J/cm2, 31.4 J/cm2, and 25.5 J/cm2, respectively. The pulse duration of the laser was 250 μsec and the repetition rate was 4 Hz. The mean length of the total occlusions was 5.3 ± 2.0 cm (range 0.5 cm to 8.0 cm). Successful recanalization was obtained in 16/16 lesions without angiographic vessel perforation. Angiographically significant residual stenoses (>50%)remained in every case following successful laser recanalization. Histologically there was minimal evidence of thermal or acoustic tissue injury; however, in 4 of 16 arteries there was evidence of deep arterial dissection following laser recanalization. We conclude that this lensed fiber coupled with a holmium:YAG laser is a safe and effective method for crossing total occlusions in the relatively straight iliac arteries of this animal model.",

keywords = "atherosclerotic swine model, laser angioplasty, silica lenses",

author = "White, {Christopher J.} and Ramee, {Stephen R.} and Collins, {Tyrone J.} and Mesa, {Juan E.} and Paulsen, {Daniel B.} and Murgo, {Joseph P.}",

year = "1991",

doi = "10.1002/lsm.1900110308",

language = "English (US)",

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pages = "250--256",

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T1 - Recanalization of arterial occlusions with a lensed fiber and a holmium:YAG laser

AU - White, Christopher J.

AU - Ramee, Stephen R.

AU - Collins, Tyrone J.

AU - Mesa, Juan E.

AU - Paulsen, Daniel B.

AU - Murgo, Joseph P.

PY - 1991

Y1 - 1991

N2 - Laser recanalization of totally occluded swine iliac arteries was performed to assess the safety and efficacy of a lensed fiber laser angioplasty system with a holmium:YAG (2.1 μm) laser. Silica lenses of 1.0 mm, 1.3 mm, and 1.5 mm in diameter attached to the distal end of a 300‐μm diameter silica fiber delivered fluences of 79.5 J/cm2, 31.4 J/cm2, and 25.5 J/cm2, respectively. The pulse duration of the laser was 250 μsec and the repetition rate was 4 Hz. The mean length of the total occlusions was 5.3 ± 2.0 cm (range 0.5 cm to 8.0 cm). Successful recanalization was obtained in 16/16 lesions without angiographic vessel perforation. Angiographically significant residual stenoses (>50%)remained in every case following successful laser recanalization. Histologically there was minimal evidence of thermal or acoustic tissue injury; however, in 4 of 16 arteries there was evidence of deep arterial dissection following laser recanalization. We conclude that this lensed fiber coupled with a holmium:YAG laser is a safe and effective method for crossing total occlusions in the relatively straight iliac arteries of this animal model.

AB - Laser recanalization of totally occluded swine iliac arteries was performed to assess the safety and efficacy of a lensed fiber laser angioplasty system with a holmium:YAG (2.1 μm) laser. Silica lenses of 1.0 mm, 1.3 mm, and 1.5 mm in diameter attached to the distal end of a 300‐μm diameter silica fiber delivered fluences of 79.5 J/cm2, 31.4 J/cm2, and 25.5 J/cm2, respectively. The pulse duration of the laser was 250 μsec and the repetition rate was 4 Hz. The mean length of the total occlusions was 5.3 ± 2.0 cm (range 0.5 cm to 8.0 cm). Successful recanalization was obtained in 16/16 lesions without angiographic vessel perforation. Angiographically significant residual stenoses (>50%)remained in every case following successful laser recanalization. Histologically there was minimal evidence of thermal or acoustic tissue injury; however, in 4 of 16 arteries there was evidence of deep arterial dissection following laser recanalization. We conclude that this lensed fiber coupled with a holmium:YAG laser is a safe and effective method for crossing total occlusions in the relatively straight iliac arteries of this animal model.

KW - atherosclerotic swine model

KW - laser angioplasty

KW - silica lenses

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Recanalization of arterial occlusions with a lensed fiber and a holmium:YAG laser

Abstract

Keywords

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