Rearrangement of chromatin domains in cancer and development

J. L. Roti Roti; D. Gius; R. P. VanderWaal; M. Xu

Rearrangement of chromatin domains in cancer and development

J. L. Roti Roti, D. Gius, R. P. VanderWaal, M. Xu

Research output: Contribution to journal › Review article › peer-review

Abstract

Both the accomplishment of developmental programs and neoplastic transformation are linked to changes in the long-range organization of chromatin, in particular, DNA loop domains. The development of new methods that allow the study of interactions between the bases of DNA loops and the proteins of the nuclear matrix will help our understanding of the molecular mechanisms in such changes. These methods should also allow the establishment of a fingerprint "signature" for many cancers that may serve for diagnostic purposes.

Original language	English (US)
Pages (from-to)	54-60
Number of pages	7
Journal	Journal of Cellular Biochemistry
Volume	80
Issue number	SUPPL. 35
State	Published - 2000
Externally published	Yes

Keywords

Cancer
DNA loop domains
Development
Fingerprinting
Nuclear matrix

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Cite this

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keywords = "Cancer, DNA loop domains, Development, Fingerprinting, Nuclear matrix",

author = "{Roti Roti}, {J. L.} and D. Gius and VanderWaal, {R. P.} and M. Xu",

year = "2000",

language = "English (US)",

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journal = "Journal of Cellular Biochemistry",

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T1 - Rearrangement of chromatin domains in cancer and development

AU - Roti Roti, J. L.

AU - Gius, D.

AU - VanderWaal, R. P.

AU - Xu, M.

PY - 2000

Y1 - 2000

N2 - Both the accomplishment of developmental programs and neoplastic transformation are linked to changes in the long-range organization of chromatin, in particular, DNA loop domains. The development of new methods that allow the study of interactions between the bases of DNA loops and the proteins of the nuclear matrix will help our understanding of the molecular mechanisms in such changes. These methods should also allow the establishment of a fingerprint "signature" for many cancers that may serve for diagnostic purposes.

AB - Both the accomplishment of developmental programs and neoplastic transformation are linked to changes in the long-range organization of chromatin, in particular, DNA loop domains. The development of new methods that allow the study of interactions between the bases of DNA loops and the proteins of the nuclear matrix will help our understanding of the molecular mechanisms in such changes. These methods should also allow the establishment of a fingerprint "signature" for many cancers that may serve for diagnostic purposes.

KW - Cancer

KW - DNA loop domains

KW - Development

KW - Fingerprinting

KW - Nuclear matrix

UR - http://www.scopus.com/inward/record.url?scp=37649026097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37649026097&partnerID=8YFLogxK

M3 - Review article

AN - SCOPUS:37649026097

SN - 0730-2312

VL - 80

SP - 54

EP - 60

JO - Journal of Cellular Biochemistry

JF - Journal of Cellular Biochemistry

IS - SUPPL. 35

ER -

Rearrangement of chromatin domains in cancer and development

Abstract

Keywords

ASJC Scopus subject areas

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Cite this