Abstract
Rearrangements of T-cell receptor β-chain genes are usually found on both chromosomal homologues, occurring by both deletional and non-deletional mechanisms. Two constant-region (Cβ) genes have been identified previously and at least one is transcribed in every helper or cytotoxic T cell tested, but the choice of Cβ gene expression is not correlated with the specialized functions of these T lymphocytes. By contrast, four of five suppressor T-cell hybridomas examined have deleted all known joining (J β) gene segments and Cβ genes and therefore may have antigen receptors encoded by different T-cell receptor gene families.
Original language | English (US) |
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Pages (from-to) | 647-653 |
Number of pages | 7 |
Journal | Nature |
Volume | 313 |
Issue number | 6004 |
DOIs | |
State | Published - 1985 |
ASJC Scopus subject areas
- General