Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

Mitchell Kronenberg, Joan Goverman, Regina Haars, Marie Malissen, Ellen Kraig, Laurie Phillips, Terry Delovitch, Nicole Suciu-Foca, Leroy Hood

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

Rearrangements of T-cell receptor β-chain genes are usually found on both chromosomal homologues, occurring by both deletional and non-deletional mechanisms. Two constant-region (Cβ) genes have been identified previously and at least one is transcribed in every helper or cytotoxic T cell tested, but the choice of Cβ gene expression is not correlated with the specialized functions of these T lymphocytes. By contrast, four of five suppressor T-cell hybridomas examined have deleted all known joining (J β) gene segments and Cβ genes and therefore may have antigen receptors encoded by different T-cell receptor gene families.

Original languageEnglish (US)
Pages (from-to)647-653
Number of pages7
JournalNature
Volume313
Issue number6004
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • General

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