Real-world multicenter analysis of clinical outcomes and safety of meropenem-vaborbactam in patients treated for serious gram-negative bacterial infections

Sara Alosaimy; Sarah C.J. Jorgensen; Abdalhamid M. Lagnf; Sarah Melvin; Ryan P. Mynatt; Travis J. Carlson; Kevin W. Garey; David Allen; Veena Venugopalan; Michael Veve; Vasilios Athans; Stephen Saw; Christine N. Yost; Susan L. Davis; Michael J. Rybak

doi:10.1093/ofid/ofaa051

Real-world multicenter analysis of clinical outcomes and safety of meropenem-vaborbactam in patients treated for serious gram-negative bacterial infections

Sara Alosaimy, Sarah C.J. Jorgensen, Abdalhamid M. Lagnf, Sarah Melvin, Ryan P. Mynatt, Travis J. Carlson, Kevin W. Garey, David Allen, Veena Venugopalan, Michael Veve, Vasilios Athans, Stephen Saw, Christine N. Yost, Susan L. Davis, Michael J. Rybak

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Fourty patients were treated with meropenem-vaborbactam (MEV) for serious Gram-negative bacterial (GNB) infections. Carbapenem-resistant Enterobacteriaceae (CRE) comprised 80.0% of all GNB infections. Clinical success occurred in 70.0% of patients. Mortality and recurrence at 30 days were 7.5% and 12.5%, respectively. One patient experienced a probable rash due to MEV.

Original language	English (US)
Article number	ofaa051
Journal	Open Forum Infectious Diseases
Volume	7
Issue number	3
DOIs	https://doi.org/10.1093/ofid/ofaa051
State	Published - Mar 1 2020
Externally published	Yes

Keywords

Carbapenem-resistant Enterobacteriaceae
Gram-negative infections
Meropenem-vaborbactam
Multidrug-resistant

ASJC Scopus subject areas

Oncology
Infectious Diseases

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10.1093/ofid/ofaa051

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Alosaimy, S., Jorgensen, S. C. J., Lagnf, A. M., Melvin, S., Mynatt, R. P., Carlson, T. J., Garey, K. W., Allen, D., Venugopalan, V., Veve, M., Athans, V., Saw, S., Yost, C. N., Davis, S. L., & Rybak, M. J. (2020). Real-world multicenter analysis of clinical outcomes and safety of meropenem-vaborbactam in patients treated for serious gram-negative bacterial infections. Open Forum Infectious Diseases, 7(3), Article ofaa051. https://doi.org/10.1093/ofid/ofaa051

Alosaimy, S, Jorgensen, SCJ, Lagnf, AM, Melvin, S, Mynatt, RP, Carlson, TJ, Garey, KW, Allen, D, Venugopalan, V, Veve, M, Athans, V, Saw, S, Yost, CN, Davis, SL & Rybak, MJ 2020, 'Real-world multicenter analysis of clinical outcomes and safety of meropenem-vaborbactam in patients treated for serious gram-negative bacterial infections', Open Forum Infectious Diseases, vol. 7, no. 3, ofaa051. https://doi.org/10.1093/ofid/ofaa051

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abstract = "Fourty patients were treated with meropenem-vaborbactam (MEV) for serious Gram-negative bacterial (GNB) infections. Carbapenem-resistant Enterobacteriaceae (CRE) comprised 80.0% of all GNB infections. Clinical success occurred in 70.0% of patients. Mortality and recurrence at 30 days were 7.5% and 12.5%, respectively. One patient experienced a probable rash due to MEV.",

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AU - Melvin, Sarah

AU - Mynatt, Ryan P.

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Real-world multicenter analysis of clinical outcomes and safety of meropenem-vaborbactam in patients treated for serious gram-negative bacterial infections

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Keywords

ASJC Scopus subject areas

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