@inbook{d3c17d98e6ff4b9f9a31cdfbb809fefa,
title = "Reactive oxygen species in normal and tumor stem cells",
abstract = "Reactive oxygen species (ROS) play an important role in determining the fate of normal stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self-renewal. Increases in ROS production cause stem cell proliferation/differentiation, senescence, and apoptosis in a dose-dependent manner, leading to their exhaustion. Therefore, the production of ROS in stem cells is tightly regulated to ensure that they have the ability to maintain tissue homeostasis and repair damaged tissues for the life span of an organism. In this chapter, we discuss how the production of ROS in normal stem cells is regulated by various intrinsic and extrinsic factors and how the fate of these cells is altered by the dysregulation of ROS production under various pathological conditions. In addition, the implications of the aberrant production of ROS by tumor stem cells for tumor progression and treatment are also discussed.",
keywords = "Adult stem cells, Apoptosis, Differentiation, Embryonic stem cells, Hematopoietic stem cells, Hypoxia, Ionizing radiation, Reactive oxygen species, Senescence, Tumor stem cells",
author = "Daohong Zhou and Lijian Shao and Spitz, {Douglas R.}",
note = "Funding Information: We apologize to the authors whose contributions were not directly cited owing to space limitations. The authors thank the previous and current members of Dr. Zhou's Laboratory for their work and support and Gareth Smith and Shawn Roach for their graphic design assistance. The research conducted in Dr. Zhou's Laboratory was supported in part by grants from the National Institutes of Health (R01-CA122023 and AI080421) and a grant from the Edward P. Evans Foundation and the Arkansas Research Alliance Scholarship from the Arkansas Science & Technology Authority. Dr. Spitz was supported by R01CA182804, R01CA133114, and R21CA161182.",
year = "2014",
doi = "10.1016/B978-0-12-420117-0.00001-3",
language = "English (US)",
series = "Advances in Cancer Research",
publisher = "Academic Press Inc.",
pages = "1--67",
booktitle = "Advances in Cancer Research",
address = "United States",
}