Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases

Danielle A. Callaway, Jean X Jiang

Research output: Contribution to journalArticlepeer-review

250 Scopus citations


Osteoclasts are cells derived from bone marrow macrophages and are important in regulating bone resorption during bone homeostasis. Understanding what drives osteoclast differentiation and activity is important when studying diseases characterized by heightened bone resorption relative to formation, such as osteoporosis. In the last decade, studies have indicated that reactive oxygen species (ROS), including superoxide and hydrogen peroxide, are crucial components that regulate the differentiation process of osteoclasts. However, there are still many unanswered questions that remain. This review will examine the mechanisms by which ROS can be produced in osteoclasts as well as how it may affect osteoclast differentiation and activity through its actions on osteoclastogenesis signaling pathways. In addition, the contribution of ROS to the aging-associated disease of osteoporosis will be addressed and how targeting ROS may lead to the development of novel therapeutic treatment options.

Original languageEnglish (US)
Pages (from-to)359-370
Number of pages12
JournalJournal of Bone and Mineral Metabolism
Issue number4
StatePublished - Mar 26 2015


  • Osteoclast
  • Osteoclastogenesis
  • Oxidative stress
  • Reactive oxygen species

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine


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