Reactive oxygen species and chronic kidney disease

Young Hyun You, Kumar Sharma

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Chronic kidney disease (CKD) is a major cause of end-stage kidney disease and largely contributed to by disease states such as diabetes, obesity, and hypertension. Reactive oxygen species (ROS) generation has been considered to be a major contributor to the initiation and propagation of CKD. In this chapter, we review the data supporting the major contribution of increased reactive oxygen species generation to CKD. NADPH oxidases will be considered as a potential source of ROS generation in the kidney. Inhibition of ROS generation as a potential therapeutic strategy will be discussed in light of recent preclinical and clinical data. Understanding the role of ROS in CKD requires better definition of the sources and types of ROS generated, and a clearer understanding of the pathogenic roles of each ROS species before a logical, targeted approach to treatment of CKD by ROS inhibition can be considered.

Original languageEnglish (US)
Title of host publicationSystems Biology of Free Radicals and Antioxidants
PublisherSpringer-Verlag Berlin Heidelberg
Pages2645-2658
Number of pages14
ISBN (Electronic)9783642300189
ISBN (Print)3642300170, 9783642300172
DOIs
StatePublished - May 1 2012
Externally publishedYes

Keywords

  • Diabetes
  • Fibrosis
  • Hydrogen peroxide
  • Hydroxyl radical
  • Inflammation
  • NADPH oxidase
  • Peroxynitrite
  • Superoxide

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    You, Y. H., & Sharma, K. (2012). Reactive oxygen species and chronic kidney disease. In Systems Biology of Free Radicals and Antioxidants (pp. 2645-2658). Springer-Verlag Berlin Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_111