Reactive oxygen intermediates, molecular damage, and aging

Relation to melatonin

Russel J Reiter, Juan M. Guerrero, Joaquin J. Garcia, Dario Acuña-Castroviejo

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Melatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger and indirect antioxidant. In terms of its scavenging activity, melatonin has been shown to quench the hydroxyl radical, superoxide anion radical, singlet oxygen, peroxyl radical, and the peroxynitrite anion. Additionally, melatonin's antioxidant actions probably derive from its stimulatory effect on superoxide dismutase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase and its inhibitory action on nitric oxide synthase. Finally, melatonin acts to stabilize cell membranes, thereby making them more resistant to oxidative attack. Melatonin is devoid of prooxidant actions. In models of oxidative stress, melatonin has been shown to resist lipid peroxidation induced by paraquat, lipopolysaccharide, ischemia reperfusion, L-cysteine, potassium cyanide, cadmium chloride, glutathione depletion, alloxan, and alcohol ingestion. Likewise, free radical damage to DNA induced by ionizing radiation, the chemical carcinogen safrole, lipopolysaccharide, and kainic acid are inhibited by melatonin. These findings illustrate that melatonin, due to its high lipid solubility and modest aqueous solubility, is able to protect macromolecules in all parts of the cell from oxidative damage. Melatonin also prevents the inhibitory action of ruthenium red at the level of the mitochondria, thereby promoting ATP production. In humans, the total antioxidative capacity of serum is related to melatonin levels. Thus, the reduction in melatonin with age may be a factor in increased oxidative damage in the elderly.

Original languageEnglish (US)
Pages (from-to)410-424
Number of pages15
JournalAnnals of the New York Academy of Sciences
Volume854
DOIs
StatePublished - 1998

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Melatonin
Aging of materials
Oxygen
Superoxides
Solubility
Lipopolysaccharides
Damage
Intermediate
Safrole
Antioxidants
Potassium Cyanide
Lipids
Ruthenium Red
Cadmium Chloride
Singlet Oxygen
Free Radical Scavengers
Alloxan
Paraquat
Mitochondria
Peroxynitrous Acid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Reactive oxygen intermediates, molecular damage, and aging : Relation to melatonin. / Reiter, Russel J; Guerrero, Juan M.; Garcia, Joaquin J.; Acuña-Castroviejo, Dario.

In: Annals of the New York Academy of Sciences, Vol. 854, 1998, p. 410-424.

Research output: Contribution to journalArticle

Reiter, Russel J ; Guerrero, Juan M. ; Garcia, Joaquin J. ; Acuña-Castroviejo, Dario. / Reactive oxygen intermediates, molecular damage, and aging : Relation to melatonin. In: Annals of the New York Academy of Sciences. 1998 ; Vol. 854. pp. 410-424.
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