Reactive non-sexually related acute genital ulcers associated with COVID-19

Jill M. Krapf, Rachel K. Casey, Andrew T. Goldstein

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Acute genital ulcers (AGU), known as Lipschu¨tz ulcers, are painful vulvar ulcers typically affecting non-sexually active girls and women. AGU have been associated with viral infections, namely, Epstein-Barr virus (EBV). Here, we describe a case of AGU in the setting of SARS-CoV-2 in a non-sexually active adolescent girl hospitalised for pain control and urinary retention, who failed a course of oral corticosteroids and then improved with colchicine. Testing for herpes simplex virus, EBV and Behcet's syndrome were all negative. Testing for SARS-CoV-2 was positive. COVID-19 increases cytokines such as tumour necrosis factor alpha, which has been shown to affect endothelial cell adhesion and neutrophil chemotaxis, leading to aphthosis.

Original languageEnglish (US)
Article numbere242653
JournalBMJ case reports
Issue number5
StatePublished - May 5 2021
Externally publishedYes


  • dermatology
  • genital ulcers
  • infectious diseases
  • vulvovaginal disorders

ASJC Scopus subject areas

  • Medicine(all)


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