Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat

Judy C. Triplett, Aaron M. Swomley, Jessime Kirk, Kelly M. Grimes, Kaitilyn N. Lewis, Miranda E. Orr, Karl A Rodriguez, Jian Cai, Jon B. Klein, Rochelle Buffenstein, D. Allan Butterfield

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Aging is the greatest risk factor for developing neurodegenerative diseases, which are associated with diminished neurotransmission as well as neuronal structure and function. However, several traits seemingly evolved to avert or delay age-related deterioration in the brain of the longest-lived rodent, the naked mole-rat (NMR). The NMR remarkably also exhibits negligible senescence, maintaining an extended healthspan for ~75 % of its life span. Using a proteomic approach, statistically significant changes with age in expression and/or phosphorylation levels of proteins associated with neurite outgrowth and neurotransmission were identified in the brain of the NMR and include: cofilin-1; collapsin response mediator protein 2; actin depolymerizing factor; spectrin alpha chain; septin-7; syntaxin-binding protein 1; synapsin-2 isoform IIB; and dynamin 1. We hypothesize that such changes may contribute to the extended lifespan and healthspan of the NMR.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalNeurochemical Research
DOIs
StateAccepted/In press - Mar 2 2016

Keywords

  • Aging
  • Naked mole-rat
  • Neurite outgrowth
  • Neurotransmission
  • Phosphoproteomics
  • Proteomics

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Biochemistry

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