RATE OF ACCUMULATION OF ACETYLCHOLINE IN DISCRETE REGIONS OF THE RAT BRAIN AFTER DICHLORVOS TREATMENT

W. B. Stavinoha, A. T. Modak, S. T. Weintraub

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Abstract

Abstract– The time course for accumulation of acetylcholine was measured in rat brain regions after treatment with 15 mg/kg, i.v., dichlorvos. With this dose of dichlorvos 84‐96% of the brain cholinester‐ase is inhibited within 1 min. After killing and concomitant enzyme inactivation through microwave irradiation, the acetylcholine levels were measured by pyrolysis‐gas chromatography. In the brain regions studied, the striatum had the highest rate of accumulation of acetylcholine and the cerebellum had the lowest. The calculated turnover time in minutes for the regions of the brain were cerebral cortex 0.9; hippocampus 1; striatum 1.4; cerebellum 1.7; medulla‐pons 2.2; midbrain 4.5; thalamus 5.6.

Original languageEnglish (US)
Pages (from-to)1375-1378
Number of pages4
JournalJournal of Neurochemistry
Volume27
Issue number6
DOIs
StatePublished - Dec 1976

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ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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