Rate dependence of human visual cortical response due to brief stimulation: An event-related fMRI study

Bahadir Ozus, Ho Ling Liu, Lin Chen, Meenakshi B. Iyer, Peter T. Fox, Jia Hong Gao

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The human brain response to a wide range of visual stimulus rates presented over a prolonged time period has been investigated by various neuroimaging techniques. However, to date, no imaging study has been performed to study the dynamic human brain response to various stimulus rates when presented in a short time. This report describes activation in the human brain due to brief visual stimulus presentation (1 s) for stimulus rates varying from 1 to 20 Hz using event-related functional MRI (fMRI). Our results show that the amplitude of the fMRI response increases with the stimulus frequency and plateaus at 6 Hz. This finding differs slightly from the results of previous blocked task paradigm experiments (with a longer time of stimulus presentation), in which the response peaks at approximately 8 Hz and then decreases. Our results are in close agreement with previously published psychophysical studies, suggesting that the fMRI signal in this experiment is indicative of cortical activity related to visual processing.

Original languageEnglish (US)
Pages (from-to)21-25
Number of pages5
JournalMagnetic Resonance Imaging
Volume19
Issue number1
DOIs
StatePublished - Apr 18 2001

Keywords

  • Event-related
  • FMRI
  • MRI
  • Stimulus frequency
  • Visual cortex

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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