Rare earth nanocomposites based on chitosan platforms for biological applications

Zannatul Yasmin, Maogen Zhang, Waldemar Gorski, Saher Maswadi, Randolph Glickman, Kelly L. Nash

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Chitosan (CHIT), a natural biopolymer, has established its applicability in numerous studies including, tissue scaffolds, topical antimicrobial agents, glucose biosensors and drug delivery platforms. Among these applications, biosensors utilizing CHIT has been championed due its excellent film-forming ability, biocompatibility, good adhesion, non-toxicity, and susceptibility to chemical modification due to the presence of plentiful amino groups and hydroxyl groups. The challenge in development of many biosensing materials is that they should offer robust and tunable characteristics (fluorescence, magnetic, thermal, etc.) while remaining biocompatible. In this work, a facile method was developed to synthesize biocompatible hetero-nanoparticles which inherently display multifunctionality based on a few interchangeable components. As an example, we present a system composed of rare earth metal oxide (REMO) nanoparticles, Er doped Y2O3, with the attachment of gold nanostructures using CHIT. The resulting REMO@CHIT@Au0 hybrid nanoparticles are capable of displaying tunable optical properties due to the surface plasmon resonance of the gold nanoparticles useful to photoacoustic applications. An overview of the nanostructure components are given followed by morphological and spectroscopic analyses. The results of the characterizations are the focus of our future work towards the applicability of these systems to biological sensing, detection and contrast agents.

Original languageEnglish (US)
Title of host publicationRare-Earth-Based Materials
Pages18-23
Number of pages6
DOIs
StatePublished - Dec 1 2012
Event2012 MRS Spring Meeting - San Francisco, CA, United States
Duration: Apr 9 2012Apr 13 2012

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1471
ISSN (Print)0272-9172

Other

Other2012 MRS Spring Meeting
CountryUnited States
CitySan Francisco, CA
Period4/9/124/13/12

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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