Rapidly growing collagenomas in multiple endocrine neoplasia type I

Yang Xia; Thomas N. Darling

doi:10.1016/j.jaad.2006.11.005

Rapidly growing collagenomas in multiple endocrine neoplasia type I

Yang Xia, Thomas N. Darling

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Patients with multiple endocrine neoplasia type I (MEN-I) frequently develop skin lesions including collagenomas, angiofibromas, and lipomas. We report a patient with MEN-I who exhibited rapid growth of multiple collagenomas after pancreatic enucleation of a vasoactive intestinal peptide-secreting tumor (VIPoma) and excision of multiple pancreatic masses. Five of the collagenomas were protuberant, with the bulk of the lesion protruding above the skin. Histologic analysis of the collagenomas revealed broad collagen bundles in a haphazard arrangement and decreased elastic fibers. Rapid growth of protuberant collagenomas appears to be unusual in MEN-I, but we suggest that MEN-I be considered in patients with apparent eruptive collagenoma.

Original language	English (US)
Pages (from-to)	877-880
Number of pages	4
Journal	Journal of the American Academy of Dermatology
Volume	56
Issue number	5
DOIs	https://doi.org/10.1016/j.jaad.2006.11.005
State	Published - May 2007
Externally published	Yes

ASJC Scopus subject areas

Dermatology

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10.1016/j.jaad.2006.11.005

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title = "Rapidly growing collagenomas in multiple endocrine neoplasia type I",

abstract = "Patients with multiple endocrine neoplasia type I (MEN-I) frequently develop skin lesions including collagenomas, angiofibromas, and lipomas. We report a patient with MEN-I who exhibited rapid growth of multiple collagenomas after pancreatic enucleation of a vasoactive intestinal peptide-secreting tumor (VIPoma) and excision of multiple pancreatic masses. Five of the collagenomas were protuberant, with the bulk of the lesion protruding above the skin. Histologic analysis of the collagenomas revealed broad collagen bundles in a haphazard arrangement and decreased elastic fibers. Rapid growth of protuberant collagenomas appears to be unusual in MEN-I, but we suggest that MEN-I be considered in patients with apparent eruptive collagenoma.",

author = "Yang Xia and Darling, {Thomas N.}",

note = "Funding Information: Supported by a Clinical Scientist Development Award from the Doris Duke Charitable Foundation. ",

year = "2007",

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doi = "10.1016/j.jaad.2006.11.005",

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AU - Darling, Thomas N.

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AB - Patients with multiple endocrine neoplasia type I (MEN-I) frequently develop skin lesions including collagenomas, angiofibromas, and lipomas. We report a patient with MEN-I who exhibited rapid growth of multiple collagenomas after pancreatic enucleation of a vasoactive intestinal peptide-secreting tumor (VIPoma) and excision of multiple pancreatic masses. Five of the collagenomas were protuberant, with the bulk of the lesion protruding above the skin. Histologic analysis of the collagenomas revealed broad collagen bundles in a haphazard arrangement and decreased elastic fibers. Rapid growth of protuberant collagenomas appears to be unusual in MEN-I, but we suggest that MEN-I be considered in patients with apparent eruptive collagenoma.

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Rapidly growing collagenomas in multiple endocrine neoplasia type I

Abstract

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