Rapidly growing collagenomas in multiple endocrine neoplasia type I

Yang Xia, Thomas N. Darling

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Patients with multiple endocrine neoplasia type I (MEN-I) frequently develop skin lesions including collagenomas, angiofibromas, and lipomas. We report a patient with MEN-I who exhibited rapid growth of multiple collagenomas after pancreatic enucleation of a vasoactive intestinal peptide-secreting tumor (VIPoma) and excision of multiple pancreatic masses. Five of the collagenomas were protuberant, with the bulk of the lesion protruding above the skin. Histologic analysis of the collagenomas revealed broad collagen bundles in a haphazard arrangement and decreased elastic fibers. Rapid growth of protuberant collagenomas appears to be unusual in MEN-I, but we suggest that MEN-I be considered in patients with apparent eruptive collagenoma.

Original languageEnglish (US)
Pages (from-to)877-880
Number of pages4
JournalJournal of the American Academy of Dermatology
Issue number5
StatePublished - May 2007
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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