Rapid Uptake of Dietary Cholesterol by Hyperplastic Liver Nodules and Primary Hepatomas

Brian J. Horton, Glen E. Mott, Henry C. Pitot, Stanley Goldfarb

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Hyperplastic liver nodules and primary hepatomas induced by 2-acetylaminofluorene take up cholesterol-3H, given p.o., at a rate only slightly less than that in normal liver, and 10 to 30-fold greater than that reported for transplantable hepatomas. In the case of primary hepatomas, the rate of uptake appeared to be related to the degree of differentiation and hence a function of tumor progression. Previous studies on regulation of cholesterol synthesis in primary hepatomas and cholesterol uptake studies in transplantable hepatomas may need to be reinterpreted in view of these results.

Original languageEnglish (US)
Pages (from-to)460-464
Number of pages5
JournalCancer Research
Volume33
Issue number3
StatePublished - Mar 1 1973
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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