Rapid replacement of serum albumin in patients receiving total parenteral nutrition

T. C. Hardin, C. P. Page, W. H. Schwesinger

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The albumin deficit (AD) of 13 malnourished patients with serum albumin concentrations (SAC) of less than 3.0 grams per deciliter was estimated using a simple equation. The AD was replaced over a period of 24 to 72 hours as a component of the formulation of total parenteral nutrition (TPN). AD was estimated assuming a volume of distribution of 3 deciliters per kilogram of actual body weight and a minimum acceptable SAC of 3.5 grams per deciliter. The mean AD was 200 ± 94 grams (x ± standard deviation), the average dose administered was 206 ± 97 grams. TPN regimens provided 42.0 ± 8.5 nonprotein kilocalories per kilogram with a nonprotein calorie to nitrogen ratio of 125 to 150:1. The SAC increased from 2.36 ± 0.38 grams per deciliter to 3.46 ± 0.26 grams per deciliter immediately after replacement. At follow-up study, the SAC at 6.4 ± 1.5 days yielded a SAC value of 3.35 ± 0.30 grams per deciliter, indicating no significant decrease from immediate replacement values. AD can be easily estimated, rapidly replaced and maintained with adequate nutritional support.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalSurgery Gynecology and Obstetrics
Issue number4
StatePublished - Dec 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology


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