Rapid Proliferation Compensates for Defective Filamentation in Candida albicans Pathogenesis

David Kadosh

doi:10.1016/j.tim.2021.08.006

Rapid Proliferation Compensates for Defective Filamentation in Candida albicans Pathogenesis

David Kadosh

Department of Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Short survey › peer-review

Abstract

A recent study (Dunker et al.) has shown that a Candida albicans mutant, defective for filamentation, is fully virulent due to rapid cellular proliferation in host tissues. These findings challenge the current paradigm in C. albicans pathogenesis and suggest that defects in one virulence property can be compensated for by enhancements in another.

Original language	English (US)
Pages (from-to)	867-868
Number of pages	2
Journal	Trends in Microbiology
Volume	29
Issue number	10
DOIs	https://doi.org/10.1016/j.tim.2021.08.006
State	Published - Oct 2021

Keywords

Candida albicans
cellular proliferation
filaments
metabolic adaptation
morphology
pathogenesis
yeast

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Virology
Microbiology

Access to Document

10.1016/j.tim.2021.08.006

Cite this

@article{08315256f03c4141990fa1c1264a897a,

title = "Rapid Proliferation Compensates for Defective Filamentation in Candida albicans Pathogenesis",

abstract = "A recent study (Dunker et al.) has shown that a Candida albicans mutant, defective for filamentation, is fully virulent due to rapid cellular proliferation in host tissues. These findings challenge the current paradigm in C. albicans pathogenesis and suggest that defects in one virulence property can be compensated for by enhancements in another.",

keywords = "Candida albicans, cellular proliferation, filaments, metabolic adaptation, morphology, pathogenesis, yeast",

author = "David Kadosh",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = oct,

doi = "10.1016/j.tim.2021.08.006",

language = "English (US)",

volume = "29",

pages = "867--868",

journal = "Trends in Microbiology",

issn = "0966-842X",

publisher = "Elsevier Ltd",

number = "10",

}

TY - JOUR

T1 - Rapid Proliferation Compensates for Defective Filamentation in Candida albicans Pathogenesis

AU - Kadosh, David

PY - 2021/10

Y1 - 2021/10

N2 - A recent study (Dunker et al.) has shown that a Candida albicans mutant, defective for filamentation, is fully virulent due to rapid cellular proliferation in host tissues. These findings challenge the current paradigm in C. albicans pathogenesis and suggest that defects in one virulence property can be compensated for by enhancements in another.

AB - A recent study (Dunker et al.) has shown that a Candida albicans mutant, defective for filamentation, is fully virulent due to rapid cellular proliferation in host tissues. These findings challenge the current paradigm in C. albicans pathogenesis and suggest that defects in one virulence property can be compensated for by enhancements in another.

KW - Candida albicans

KW - cellular proliferation

KW - filaments

KW - metabolic adaptation

KW - morphology

KW - pathogenesis

KW - yeast

UR - http://www.scopus.com/inward/record.url?scp=85113800351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85113800351&partnerID=8YFLogxK

U2 - 10.1016/j.tim.2021.08.006

DO - 10.1016/j.tim.2021.08.006

M3 - Short survey

C2 - 34462187

AN - SCOPUS:85113800351

SN - 0966-842X

VL - 29

SP - 867

EP - 868

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 10

ER -

Rapid Proliferation Compensates for Defective Filamentation in Candida albicans Pathogenesis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this