Rapid gas chromatographie assay for volatile anesthetics in blood

David J. Jones

doi:10.1016/0160-5402(78)90020-7

Rapid gas chromatographie assay for volatile anesthetics in blood

David J. Jones

Anesthesiology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An equilibration/direct injection gas Chromatographie method has been developed for measurement of enflurane and halothane in whole blood. The method does not require extraction of anesthetic from blood or the use of pre-column devices for preparation of the sample for application to the gas Chromatograph column. By using an "anaerobic" serum vial unit, 1 ml, standards and samples are prepared, equilibrated at 37°C and 10 μl samples of the gas phase injected into the gas Chromatograph. Technical simplicity and reproducibility permit use of this assay under a variety of online conditions.

Original language	English (US)
Pages (from-to)	155-160
Number of pages	6
Journal	Journal of Pharmacological Methods
Volume	1
Issue number	2
DOIs	https://doi.org/10.1016/0160-5402(78)90020-7
State	Published - Aug 1978

Keywords

Enflurane
Gas chromatography
Halothane
measurement

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0160-5402(78)90020-7

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N2 - An equilibration/direct injection gas Chromatographie method has been developed for measurement of enflurane and halothane in whole blood. The method does not require extraction of anesthetic from blood or the use of pre-column devices for preparation of the sample for application to the gas Chromatograph column. By using an "anaerobic" serum vial unit, 1 ml, standards and samples are prepared, equilibrated at 37°C and 10 μl samples of the gas phase injected into the gas Chromatograph. Technical simplicity and reproducibility permit use of this assay under a variety of online conditions.

AB - An equilibration/direct injection gas Chromatographie method has been developed for measurement of enflurane and halothane in whole blood. The method does not require extraction of anesthetic from blood or the use of pre-column devices for preparation of the sample for application to the gas Chromatograph column. By using an "anaerobic" serum vial unit, 1 ml, standards and samples are prepared, equilibrated at 37°C and 10 μl samples of the gas phase injected into the gas Chromatograph. Technical simplicity and reproducibility permit use of this assay under a variety of online conditions.

KW - Enflurane

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KW - Halothane

KW - measurement

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