Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure

James S. Lewis, Nathan Wiederhold, Brian L Wickes, Thomas F Patterson, James H. Jorgensen

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

We report a case of Candida glabrata candidemia that developed resistance to micafungin within 8 days of initiation of therapy in a patient without previous echinocandin exposure or other known risk factors for clinical or microbiological failure. Pre-and postresistant isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed a phenylalanine deletion at codon 659 within FKS2.

Original languageEnglish (US)
Pages (from-to)4559-4561
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number9
DOIs
StatePublished - Sep 2013

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Echinocandins
Candida glabrata
Candidemia
Phenylalanine
Codon
Therapeutics
micafungin

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

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abstract = "We report a case of Candida glabrata candidemia that developed resistance to micafungin within 8 days of initiation of therapy in a patient without previous echinocandin exposure or other known risk factors for clinical or microbiological failure. Pre-and postresistant isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed a phenylalanine deletion at codon 659 within FKS2.",
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