Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure

James S. Lewis; Nathan P. Wiederhold; Brian L. Wickes; Thomas F. Patterson; James H. Jorgensen

doi:10.1128/AAC.01144-13

Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure

James S. Lewis, Nathan P. Wiederhold, Brian L. Wickes, Thomas F. Patterson, James H. Jorgensen

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

We report a case of Candida glabrata candidemia that developed resistance to micafungin within 8 days of initiation of therapy in a patient without previous echinocandin exposure or other known risk factors for clinical or microbiological failure. Pre-and postresistant isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed a phenylalanine deletion at codon 659 within FKS2.

Original language	English (US)
Pages (from-to)	4559-4561
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	57
Issue number	9
DOIs	https://doi.org/10.1128/AAC.01144-13
State	Published - Sep 2013

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "We report a case of Candida glabrata candidemia that developed resistance to micafungin within 8 days of initiation of therapy in a patient without previous echinocandin exposure or other known risk factors for clinical or microbiological failure. Pre-and postresistant isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed a phenylalanine deletion at codon 659 within FKS2.",

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AU - Patterson, Thomas F.

AU - Jorgensen, James H.

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AB - We report a case of Candida glabrata candidemia that developed resistance to micafungin within 8 days of initiation of therapy in a patient without previous echinocandin exposure or other known risk factors for clinical or microbiological failure. Pre-and postresistant isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed a phenylalanine deletion at codon 659 within FKS2.

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Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure

Abstract

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