Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure

James S. Lewis, Nathan P. Wiederhold, Brian L. Wickes, Thomas F. Patterson, James H. Jorgensen

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

We report a case of Candida glabrata candidemia that developed resistance to micafungin within 8 days of initiation of therapy in a patient without previous echinocandin exposure or other known risk factors for clinical or microbiological failure. Pre-and postresistant isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed a phenylalanine deletion at codon 659 within FKS2.

Original languageEnglish (US)
Pages (from-to)4559-4561
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume57
Issue number9
DOIs
StatePublished - Sep 2013

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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