Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes

Kavithalakshmi Sataranatarajan; Yuji Ikeno; Alex Bokov; Denis Feliers; Himabindu Yalamanchili; Hak Joo Lee; Meenalakshmi M. Mariappan; Hooman Tabatabai-Mir; Vivian Diaz; Sanjay Prasad; Martin A. Javors; Goutam Ghosh Choudhury; Gene B. Hubbard; Jeffrey L. Barnes; Arlan Richardson; Balakuntalam S. Kasinath

doi:10.1093/gerona/glv170

Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes

Kavithalakshmi Sataranatarajan
, Yuji Ikeno
, Alex Bokov
, Denis Feliers
, Himabindu Yalamanchili
, Hak Joo Lee
, Meenalakshmi M. Mariappan
, Hooman Tabatabai-Mir
, Vivian Diaz
, Sanjay Prasad
, Martin A. Javors
, Goutam Ghosh Choudhury
, Gene B. Hubbard
, Jeffrey L. Barnes
, Arlan Richardson
, Balakuntalam S. Kasinath

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

We examined the effect of rapamycin on the life span of a mouse model of type 2 diabetes, db/db mice. At 4 months of age, male and female C57BLKSJ-lepr^db/db mice (db/db) were placed on either a control diet, lacking rapamycin or a diet containing rapamycin and maintained on these diets over their life span. Rapamycin was found to reduce the life span of the db/db mice. The median survival of male db/db mice fed the control and rapamycin diets was 349 and 302 days, respectively, and the median survival of female db/db mice fed the control and rapamycin diets was 487 and 411 days, respectively. Adjusting for gender differences, rapamycin increased the mortality risk 1.7-fold in both male and female db/db mice. End-of-life pathological data showed that suppurative inflammation was the main cause of death in the db/db mice, which is enhanced slightly by rapamycin treatment.

Original language	English (US)
Pages (from-to)	850-857
Number of pages	8
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	71
Issue number	7
DOIs	https://doi.org/10.1093/gerona/glv170
State	Published - Jul 2016

Keywords

Life span
Obesity
Toxicity
mTOR inhibition

ASJC Scopus subject areas

General Medicine

Access to Document

10.1093/gerona/glv170

Cite this

Sataranatarajan, K., Ikeno, Y., Bokov, A., Feliers, D., Yalamanchili, H., Lee, H. J., Mariappan, M. M., Tabatabai-Mir, H., Diaz, V., Prasad, S., Javors, M. A., Choudhury, G. G., Hubbard, G. B., Barnes, J. L., Richardson, A., & Kasinath, B. S. (2016). Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 71(7), 850-857. https://doi.org/10.1093/gerona/glv170

Sataranatarajan, K, Ikeno, Y, Bokov, A, Feliers, D, Yalamanchili, H, Lee, HJ, Mariappan, MM, Tabatabai-Mir, H, Diaz, V, Prasad, S, Javors, MA, Choudhury, GG, Hubbard, GB, Barnes, JL, Richardson, A & Kasinath, BS 2016, 'Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 71, no. 7, pp. 850-857. https://doi.org/10.1093/gerona/glv170

@article{ff88fb2832bb4614a327da1ebd1b92a1,

title = "Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes",

abstract = "We examined the effect of rapamycin on the life span of a mouse model of type 2 diabetes, db/db mice. At 4 months of age, male and female C57BLKSJ-leprdb/db mice (db/db) were placed on either a control diet, lacking rapamycin or a diet containing rapamycin and maintained on these diets over their life span. Rapamycin was found to reduce the life span of the db/db mice. The median survival of male db/db mice fed the control and rapamycin diets was 349 and 302 days, respectively, and the median survival of female db/db mice fed the control and rapamycin diets was 487 and 411 days, respectively. Adjusting for gender differences, rapamycin increased the mortality risk 1.7-fold in both male and female db/db mice. End-of-life pathological data showed that suppurative inflammation was the main cause of death in the db/db mice, which is enhanced slightly by rapamycin treatment.",

keywords = "Life span, Obesity, Toxicity, mTOR inhibition",

author = "Kavithalakshmi Sataranatarajan and Yuji Ikeno and Alex Bokov and Denis Feliers and Himabindu Yalamanchili and Lee, \{Hak Joo\} and Mariappan, \{Meenalakshmi M.\} and Hooman Tabatabai-Mir and Vivian Diaz and Sanjay Prasad and Javors, \{Martin A.\} and Choudhury, \{Goutam Ghosh\} and Hubbard, \{Gene B.\} and Barnes, \{Jeffrey L.\} and Arlan Richardson and Kasinath, \{Balakuntalam S.\}",

year = "2016",

month = jul,

doi = "10.1093/gerona/glv170",

language = "English (US)",

volume = "71",

pages = "850--857",

journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",

issn = "1079-5006",

publisher = "Oxford University Press",

number = "7",

}

TY - JOUR

T1 - Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes

AU - Sataranatarajan, Kavithalakshmi

AU - Ikeno, Yuji

AU - Bokov, Alex

AU - Feliers, Denis

AU - Yalamanchili, Himabindu

AU - Lee, Hak Joo

AU - Mariappan, Meenalakshmi M.

AU - Tabatabai-Mir, Hooman

AU - Diaz, Vivian

AU - Prasad, Sanjay

AU - Javors, Martin A.

AU - Choudhury, Goutam Ghosh

AU - Hubbard, Gene B.

AU - Barnes, Jeffrey L.

AU - Richardson, Arlan

AU - Kasinath, Balakuntalam S.

PY - 2016/7

Y1 - 2016/7

N2 - We examined the effect of rapamycin on the life span of a mouse model of type 2 diabetes, db/db mice. At 4 months of age, male and female C57BLKSJ-leprdb/db mice (db/db) were placed on either a control diet, lacking rapamycin or a diet containing rapamycin and maintained on these diets over their life span. Rapamycin was found to reduce the life span of the db/db mice. The median survival of male db/db mice fed the control and rapamycin diets was 349 and 302 days, respectively, and the median survival of female db/db mice fed the control and rapamycin diets was 487 and 411 days, respectively. Adjusting for gender differences, rapamycin increased the mortality risk 1.7-fold in both male and female db/db mice. End-of-life pathological data showed that suppurative inflammation was the main cause of death in the db/db mice, which is enhanced slightly by rapamycin treatment.

AB - We examined the effect of rapamycin on the life span of a mouse model of type 2 diabetes, db/db mice. At 4 months of age, male and female C57BLKSJ-leprdb/db mice (db/db) were placed on either a control diet, lacking rapamycin or a diet containing rapamycin and maintained on these diets over their life span. Rapamycin was found to reduce the life span of the db/db mice. The median survival of male db/db mice fed the control and rapamycin diets was 349 and 302 days, respectively, and the median survival of female db/db mice fed the control and rapamycin diets was 487 and 411 days, respectively. Adjusting for gender differences, rapamycin increased the mortality risk 1.7-fold in both male and female db/db mice. End-of-life pathological data showed that suppurative inflammation was the main cause of death in the db/db mice, which is enhanced slightly by rapamycin treatment.

KW - Life span

KW - Obesity

KW - Toxicity

KW - mTOR inhibition

UR - https://www.scopus.com/pages/publications/84979210064

UR - https://www.scopus.com/pages/publications/84979210064#tab=citedBy

U2 - 10.1093/gerona/glv170

DO - 10.1093/gerona/glv170

M3 - Article

C2 - 26442901

AN - SCOPUS:84979210064

SN - 1079-5006

VL - 71

SP - 850

EP - 857

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 7

ER -

Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this