Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes

Kavithalakshmi Sataranatarajan, Yuji Ikeno, Alex Bokov, Denis Feliers, Himabindu Yalamanchili, Hak Joo Lee, Meenalakshmi M. Mariappan, Hooman Tabatabai-Mir, Vivian Diaz, Sanjay Prasad, Martin A Javors, Goutam Ghosh-choudhury, Gene B. Hubbard, Jeffrey L. Barnes, Arlan Richardson, Balakuntalam S Kasinath

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We examined the effect of rapamycin on the life span of a mouse model of type 2 diabetes, db/db mice. At 4 months of age, male and female C57BLKSJ-leprdb/db mice (db/db) were placed on either a control diet, lacking rapamycin or a diet containing rapamycin and maintained on these diets over their life span. Rapamycin was found to reduce the life span of the db/db mice. The median survival of male db/db mice fed the control and rapamycin diets was 349 and 302 days, respectively, and the median survival of female db/db mice fed the control and rapamycin diets was 487 and 411 days, respectively. Adjusting for gender differences, rapamycin increased the mortality risk 1.7-fold in both male and female db/db mice. End-of-life pathological data showed that suppurative inflammation was the main cause of death in the db/db mice, which is enhanced slightly by rapamycin treatment.

Original languageEnglish (US)
Pages (from-to)850-857
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume71
Issue number7
DOIs
StatePublished - 2016

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Sirolimus
Type 2 Diabetes Mellitus
Mortality
Diet
Cause of Death
Inflammation

Keywords

  • Life span
  • mTOR inhibition
  • Obesity
  • Toxicity

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes. / Sataranatarajan, Kavithalakshmi; Ikeno, Yuji; Bokov, Alex; Feliers, Denis; Yalamanchili, Himabindu; Lee, Hak Joo; Mariappan, Meenalakshmi M.; Tabatabai-Mir, Hooman; Diaz, Vivian; Prasad, Sanjay; Javors, Martin A; Ghosh-choudhury, Goutam; Hubbard, Gene B.; Barnes, Jeffrey L.; Richardson, Arlan; Kasinath, Balakuntalam S.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 71, No. 7, 2016, p. 850-857.

Research output: Contribution to journalArticle

Sataranatarajan, K, Ikeno, Y, Bokov, A, Feliers, D, Yalamanchili, H, Lee, HJ, Mariappan, MM, Tabatabai-Mir, H, Diaz, V, Prasad, S, Javors, MA, Ghosh-choudhury, G, Hubbard, GB, Barnes, JL, Richardson, A & Kasinath, BS 2016, 'Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 71, no. 7, pp. 850-857. https://doi.org/10.1093/gerona/glv170
Sataranatarajan, Kavithalakshmi ; Ikeno, Yuji ; Bokov, Alex ; Feliers, Denis ; Yalamanchili, Himabindu ; Lee, Hak Joo ; Mariappan, Meenalakshmi M. ; Tabatabai-Mir, Hooman ; Diaz, Vivian ; Prasad, Sanjay ; Javors, Martin A ; Ghosh-choudhury, Goutam ; Hubbard, Gene B. ; Barnes, Jeffrey L. ; Richardson, Arlan ; Kasinath, Balakuntalam S. / Rapamycin increases mortality in db/db mice, a mouse model of type 2 diabetes. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2016 ; Vol. 71, No. 7. pp. 850-857.
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