Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

Richard A. Miller; David E. Harrison; C. M. Astle; Joseph A. Baur; Angela Rodriguez Boyd; Rafael De Cabo; Elizabeth Fernandez; Kevin Flurkey; Martin A. Javors; James F. Nelson; Carlos J. Orihuela; Scott Pletcher; Zelton Dave Sharp; David Sinclair; Joseph W. Starnes; J. Erby Wilkinson; Nancy L. Nadon; Randy Strong

doi:10.1093/gerona/glq178

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

Richard A. Miller, David E. Harrison, C. M. Astle, Joseph A. Baur, Angela Rodriguez Boyd, Rafael De Cabo, Elizabeth Fernandez, Kevin Flurkey, Martin A. Javors, James F. Nelson, Carlos J. Orihuela, Scott Pletcher, Zelton Dave Sharp, David Sinclair, Joseph W. Starnes, J. Erby Wilkinson, Nancy L. Nadon, Randy Strong

Research output: Contribution to journal › Article › peer-review

747 Scopus citations

Abstract

Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test sites. Median survival was extended by an average of 10% in males and 18% in females. Rapamycin attenuated age-associated decline in spontaneous activity in males but not in females. Causes of death were similar in control and rapamycin-treated mice. Resveratrol (at 300 and 1200 ppm food) and simvastatin (12 and 120 ppm) did not have significant effects on survival in male or female mice. Further evaluation of rapamycin's effects on mice is likely to help delineate the role of the mammalian target of rapamycin complexes in the regulation of aging rate and age-dependent diseases and may help to guide a search for drugs that retard some or all of the diseases of aging.

Original language	English (US)
Pages (from-to)	191-201
Number of pages	11
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	66 A
Issue number	2
DOIs	https://doi.org/10.1093/gerona/glq178
State	Published - Feb 2011

Keywords

Life span
Rapamycin
Resveratrol
TOR

ASJC Scopus subject areas

General Medicine

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10.1093/gerona/glq178

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Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., De Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., Orihuela, C. J., Pletcher, S., Sharp, Z. D., Sinclair, D., Starnes, J. W., Wilkinson, J. E., Nadon, N. L., & Strong, R. (2011). Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 66 A(2), 191-201. https://doi.org/10.1093/gerona/glq178

Miller, RA, Harrison, DE, Astle, CM, Baur, JA, Boyd, AR, De Cabo, R, Fernandez, E, Flurkey, K, Javors, MA , Nelson, JF, Orihuela, CJ, Pletcher, S, Sharp, ZD, Sinclair, D, Starnes, JW, Wilkinson, JE, Nadon, NL & Strong, R 2011, 'Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 66 A, no. 2, pp. 191-201. https://doi.org/10.1093/gerona/glq178

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abstract = "Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test sites. Median survival was extended by an average of 10% in males and 18% in females. Rapamycin attenuated age-associated decline in spontaneous activity in males but not in females. Causes of death were similar in control and rapamycin-treated mice. Resveratrol (at 300 and 1200 ppm food) and simvastatin (12 and 120 ppm) did not have significant effects on survival in male or female mice. Further evaluation of rapamycin's effects on mice is likely to help delineate the role of the mammalian target of rapamycin complexes in the regulation of aging rate and age-dependent diseases and may help to guide a search for drugs that retard some or all of the diseases of aging.",

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note = "Funding Information: This work was supported by the National Institute on Aging at the National Institutes of Health (U01-AG022303 to R.A.M., U01-AG025707 and U01-AG022308 to D.E.H., R21-AG029313 to C.J.O., and U01-AG022307 and R01-AG13319 to R.S.); and the Department of Veterans Affairs (R.A.M. and R.S.). R.d.C. is supported by the Intramural Research Program of the National Institute on Aging.",

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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

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Keywords

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