Radiotherapy is not associated with an increased rate of Second Primary Tumours in Oral Squamous Carcinoma: A study of 370 patients

Ross Darius Farhadieh, Petr Otahal, Charles Geoffrey Gordon Rees, Arash Salardini, Pamela Russell, Robert Smee

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Oral Squamous Cell Carcinoma (OSCC) remains a public health scourge. Radiotherapy (RT) is a major treatment modality and has been implicated in possible formation of Second Primary Tumours (SPT). In a single centre retrospective study of 370 patients with OSCCs (1967-2004) associations between RT, diagnosis of SPTs, median SPT diagnostic time lag, Disease Free Survival (DFS) and overall survival (OS) were analysed. Sixty-eight (18.4%) patients developed metachronous SPTs. Two hundred and twenty patients (59.3%) underwent some form of RT whilst 151 (40.7%) patients were not exposed to RT. No significant increased incidence of SPTs was demonstrated in the RT group. No significant difference in SPT diagnostic time lag was noted amongst the groups. This study suggests that RT is neither a risk for SPT induction nor increases the relative diagnostic time delay of upper aero-digestive tract SPTs.

Original languageEnglish (US)
Pages (from-to)941-945
Number of pages5
JournalOral Oncology
Volume45
Issue number11
DOIs
StatePublished - Nov 2009
Externally publishedYes

Keywords

  • Oral Squamous Cell Carcinoma
  • Radiotherapy
  • Second Primary Tumours

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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