Radionuclide techniques for valvular regurgitant index: Comparison in patients with normal and depressed ventricular function

P. Nicod, J. R. Corbett, B. G. Firth, G. J. Dehmer, C. Izquierdo, R. V. Markham, L. D. Hillis, J. T. Willerson, S. E. Lewis

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We compared contrast angiography with three techniques of quantitating valvular regurgitation from radionuclide ventriculograms in 70 patients: 45 with documented regurgitation graded 1-4+, and 25 without regurgitation. The radionuclide 'regurgitant index' (ratio of L to R ventricular stroke counts) was measured from fixed end-diastolic regions of interest (method A), from separate end-diastolic and end-systolic regions of interest (method B), and from a 'stroke-volume image' (method C). Sensitivites for detecting 1+ or more regurgitation were: method A = 57.8%, method B = 37.8% and method C = 62.2%. Sensitivities for detecting 2+ or more regurgitation were: method A - 74.2%, method B = 54.8%, and method C = 77.4%. All methods were >97% specific. Interobserver coefficients of variability were: method A = 9.1%, method B = 19.2%, and method C = 5.4%. The sensitivity of each method was improved when left-ventricular ejection fractions were 0.35. No method consistently differentiated between 2+, 3+, and 4+ valvular regurgitation.

Original languageEnglish (US)
Pages (from-to)763-769
Number of pages7
JournalJournal of Nuclear Medicine
Volume23
Issue number9
StatePublished - 1982

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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