Radiobiologically based treatment plan evaluation for prostate seed implants

Courtney Knaup, Panayiotis Mavroidis, Carlos Esquivel, Dimos Baltas, Sotirios Stathakis, Gregory P Swanson, Nikos Papanikolaou

Research output: Contribution to journalArticle

Abstract

Purpose: Accurate prostate low dose-rate brachytherapy treatment plan evaluation is important for future care decisions. Presently, an evaluation is based on dosimetric quantifiers for the tumor and organs at risk. However, these do not account for effects of varying dose-rate, tumor repopulation and other biological effects. In this work, incorporation of the biological response is used to obtain more clinically relevant treatment plan evaluation. Material and methods: Eleven patients were evaluated. Each patient received a 145 Gy implant. Iodine-125 seeds were used and the treatment plans were created on the Prowess system. Based on CT images the post-implant plan was created. In the post-plan, the tumor, urethra, bladder and rectum were contoured. The biologically effective dose was used to determine the tumor control probability and the normal tissue complication probabilities for the urethra, bladder, rectum and surrounding tissue. Results: The average tumor control probability and complication probabilities for the urethra, bladder, rectum and surrounding tissue were 99%, 29%, 0%, 12% and 6%, respectively. These measures provide a simpler means for evaluation and since they include radiobiological factors, they provide more reliable estimation of the treatment outcome. Conclusions: The goal of this work was to create more clinically relevant prostate seed-implant evaluation by incorporating radiobiological measures. This resulted in a simpler descriptor of treatment plan quality and was consistent with patient outcomes.

Original languageEnglish (US)
Pages (from-to)74-83
Number of pages10
JournalJournal of Contemporary Brachytherapy
Volume3
Issue number2
DOIs
StatePublished - Jun 30 2011

Fingerprint

Prostate
Seeds
Urethra
Rectum
Neoplasms
Urinary Bladder
Organs at Risk
Therapeutics
Brachytherapy
Urinary Bladder Neoplasms
Iodine

Keywords

  • LDR
  • Prostate
  • Radiobiology
  • Treatment plan

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Radiobiologically based treatment plan evaluation for prostate seed implants. / Knaup, Courtney; Mavroidis, Panayiotis; Esquivel, Carlos; Baltas, Dimos; Stathakis, Sotirios; Swanson, Gregory P; Papanikolaou, Nikos.

In: Journal of Contemporary Brachytherapy, Vol. 3, No. 2, 30.06.2011, p. 74-83.

Research output: Contribution to journalArticle

Knaup C, Mavroidis P, Esquivel C, Baltas D, Stathakis S, Swanson GP et al. Radiobiologically based treatment plan evaluation for prostate seed implants. Journal of Contemporary Brachytherapy. 2011 Jun 30;3(2):74-83. https://doi.org/10.5114/jcb.2011.23201
Knaup, Courtney ; Mavroidis, Panayiotis ; Esquivel, Carlos ; Baltas, Dimos ; Stathakis, Sotirios ; Swanson, Gregory P ; Papanikolaou, Nikos. / Radiobiologically based treatment plan evaluation for prostate seed implants. In: Journal of Contemporary Brachytherapy. 2011 ; Vol. 3, No. 2. pp. 74-83.
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