Radiation-induced changes of structural and functional properties of human hemoglobin - I. Spectral characterization of irradiated deoxyhemoglobin

Z. Szweda-Lewandowska; M. Puchała; P. A. Osmulski

doi:10.1007/BF01209721

Radiation-induced changes of structural and functional properties of human hemoglobin - I. Spectral characterization of irradiated deoxyhemoglobin

Z. Szweda-Lewandowska, M. Puchała, P. A. Osmulski

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12 Scopus citations

Abstract

Structural changes of human deoxyhemoglobin (deoxyHb) induced by water and ethanol radicals were investigated in this study using absorption spectroscopy. Spectra of deoxyHb samples irradiated under various conditions (the atmosphere of argon or N₂O in the absence or presence of ethanol) indicate their conversion into methemoglobin (metHb), hemichrome- and cholehemichrome-like products. The absorbance at the characteristic maxima of these derivatives and also of the oxidized or reduced samples following irradiation depends on the dose of radiation and the conditions employed.

Original language	English (US)
Pages (from-to)	39-46
Number of pages	8
Journal	Radiation and Environmental Biophysics
Volume	28
Issue number	1
DOIs	https://doi.org/10.1007/BF01209721
State	Published - Mar 1989
Externally published	Yes

ASJC Scopus subject areas

General Environmental Science
Radiation
Biophysics

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abstract = "Structural changes of human deoxyhemoglobin (deoxyHb) induced by water and ethanol radicals were investigated in this study using absorption spectroscopy. Spectra of deoxyHb samples irradiated under various conditions (the atmosphere of argon or N2O in the absence or presence of ethanol) indicate their conversion into methemoglobin (metHb), hemichrome- and cholehemichrome-like products. The absorbance at the characteristic maxima of these derivatives and also of the oxidized or reduced samples following irradiation depends on the dose of radiation and the conditions employed.",

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AU - Szweda-Lewandowska, Z.

AU - Puchała, M.

AU - Osmulski, P. A.

PY - 1989/3

Y1 - 1989/3

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AB - Structural changes of human deoxyhemoglobin (deoxyHb) induced by water and ethanol radicals were investigated in this study using absorption spectroscopy. Spectra of deoxyHb samples irradiated under various conditions (the atmosphere of argon or N2O in the absence or presence of ethanol) indicate their conversion into methemoglobin (metHb), hemichrome- and cholehemichrome-like products. The absorbance at the characteristic maxima of these derivatives and also of the oxidized or reduced samples following irradiation depends on the dose of radiation and the conditions employed.

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Radiation-induced changes of structural and functional properties of human hemoglobin - I. Spectral characterization of irradiated deoxyhemoglobin

Abstract

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