Abstract
Background: The proteolytic regulation of DNA repair factors remains poorly understood. Results: Six proteins involved in nucleotide excision repair are found to be degraded by the proteasome. Conclusion: Rad25 is selected for proteasomal degradation by the Ubc4-Ufd4 pathway. Significance: Our results provide novel insights into the role of the proteasome in DNA repair.
Original language | English (US) |
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Pages (from-to) | 8606-8612 |
Number of pages | 7 |
Journal | Journal of Biological Chemistry |
Volume | 290 |
Issue number | 13 |
DOIs | |
State | Published - Mar 27 2015 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology