Rad25 protein is targeted for degradation by the Ubc4-Ufd4 pathway

Xin Bao, Jill L. Johnson, Hai Rao

Research output: Contribution to journalArticle

Abstract

Background: The proteolytic regulation of DNA repair factors remains poorly understood. Results: Six proteins involved in nucleotide excision repair are found to be degraded by the proteasome. Conclusion: Rad25 is selected for proteasomal degradation by the Ubc4-Ufd4 pathway. Significance: Our results provide novel insights into the role of the proteasome in DNA repair.

Original languageEnglish (US)
Pages (from-to)8606-8612
Number of pages7
JournalJournal of Biological Chemistry
Volume290
Issue number13
DOIs
Publication statusPublished - Mar 27 2015

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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