Race and Outcomes of Autologous Hematopoietic Cell Transplantation for Multiple Myeloma

Parameswaran N. Hari, Navneet S. Majhail, Mei Jie Zhang, Anna Hassebroek, Fareeha Siddiqui, Karen Ballen, Asad Bashey, Jenny Bird, Cesar O. Freytes, John Gibson, Gregaory Hale, Leona Holmberg, Ram Kamble, Robert A. Kyle, Hillard M. Lazarus, Charles F. LeMaistre, Fausto Loberiza, Angelo Maiolino, Philip L. McCarthy, Gustavo MiloneNancy Omondi, Donna E. Reece, Matthew Seftel, Michael Trigg, David Vesole, Brendan Weiss, Peter Wiernik, Stephanie J. Lee, J. Douglas Rizzo, Paulette Mehta

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Blacks are twice as likely to develop and die from multiple myeloma (MM), and are less likely to receive an autologous hematopoietic-cell transplant (AHCT) for MM compared to Whites. The influence of race on outcomes of AHCT for MM is not well described. We compared the probability of overall survival (OS), progression-free survival (PFS), disease progression, and nonrelapse mortality (NRM) among Black (N = 303) and White (N = 1892) recipients of AHCT for MM, who were reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) from 1995 to 2005. The Black cohort was more likely to be female, and had better Karnofsky performance scores, but lower hemoglobin and albumin levels at diagnosis. Black recipients were younger and more likely to be transplanted later in their disease course. Disease stage and treatment characteristics prior to AHCT were similar between the 2 groups. Black and White recipients had similar probabilities of 5-year OS (52% versus 47%, P = .19) and PFS (19% versus 21%, P = .64) as well as cumulative incidences of disease progression (72% versus 72%, P = .97) and NRM (9% versus 8%, P = .52). In multivariate analyses, race was not associated with any of these endpoints. Black recipients of AHCT for MM have similar outcomes compared to Whites, suggesting that the reasons underlying lower rates of AHCT in Blacks need to be studied further to ensure equal access to effective therapy.

Original languageEnglish (US)
Pages (from-to)395-402
Number of pages8
JournalBiology of Blood and Marrow Transplantation
Volume16
Issue number3
DOIs
StatePublished - Mar 2010

Keywords

  • Autologous hematopoietic cell transplantation
  • Multiple myeloma
  • Progression-free survival
  • Race
  • Survival

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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