Questioning the preclinical paradigm: Natural, extreme biology as an alternative discovery platform

Rochelle Buffenstein, O. Lynne Nelson, Kevin C. Corbit

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

The pace at which science continues to advance is astonishing. From cosmology, microprocessors, structural engineering, and DNA sequencing our lives are continually affected by science-based technology. However, progress in treating human ailments, especially age-related conditions such as cancer and Alzheimer's disease, moves at a relative snail's pace. Given that the amount of investment is not disproportionately low, one has to question why our hopes for the development of efficacious drugs for such grievous illnesses have been frustratingly unrealized. Here we discuss one aspect of drug development -rodent models - and propose an alternative approach to discovery research rooted in evolutionary experimentation. Our goal is to accelerate the conversation around how we can move towards more translative preclinical work.

Original languageEnglish (US)
Pages (from-to)913-920
Number of pages8
JournalAging
Volume6
Issue number11
DOIs
StatePublished - 2014

Keywords

  • Aging
  • Cancer resistance
  • Cardiac function
  • Extremophiles
  • Grizzly bear
  • Insulin sensitivity
  • Naked mole-rat
  • Obesity
  • Preclinical models

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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