Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans

Jack W. Kent, Michael C. Mahaney, Anthony G. Comuzzie, Harald H H Göring, Laura Almasy, Thomas D. Dyer, Shelley A. Cole, Jean W. MacCluer, John Blangero

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Circulating soluble intercellular adhesion molecule-1 (sICAM-1) is a biochemical marker of inflammation. We performed variance-components-based quantitative genetic analyses in SOLAR of sICAM-1 in 1170 individuals from Mexican American families in the San Antonio Family Heart Study. The trait is heritable (h2 = 0.50 ± 0.06, P < 10-6). Multipoint linkage analysis using a ∼10-cM microsatellite map revealed a region on Chromosome 19p near marker D19S586 showing strong evidence of linkage for sICAM-1 (empirically adjusted univariate-equivalent LOD = 4.95), coincident with the structural gene ICAM1. This region has been identified previously as a QTL for inflammatory, autoimmune, and metabolic syndrome traits. There is significant evidence (P = 0.0023) of locus heterogeneity for sICAM-1 in this sample: a subset of pedigrees contributes most of the linkage signal for sICAM-1 on Chromosome 19, suggesting a logical focus for future genetic dissection of the trait.

Original languageEnglish (US)
Pages (from-to)367-373
Number of pages7
JournalAtherosclerosis
Volume195
Issue number2
DOIs
StatePublished - Dec 2007
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 19
Quantitative Trait Loci
Intercellular Adhesion Molecule-1
Pedigree
Microsatellite Repeats
Dissection
Chromosomes
Biomarkers
Inflammation
Genes

Keywords

  • Genetic heterogeneity
  • Genome scan
  • ICAM-1
  • Inflammation
  • Mexican Americans
  • Quantitative trait locus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kent, J. W., Mahaney, M. C., Comuzzie, A. G., Göring, H. H. H., Almasy, L., Dyer, T. D., ... Blangero, J. (2007). Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans. Atherosclerosis, 195(2), 367-373. https://doi.org/10.1016/j.atherosclerosis.2006.10.005

Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans. / Kent, Jack W.; Mahaney, Michael C.; Comuzzie, Anthony G.; Göring, Harald H H; Almasy, Laura; Dyer, Thomas D.; Cole, Shelley A.; MacCluer, Jean W.; Blangero, John.

In: Atherosclerosis, Vol. 195, No. 2, 12.2007, p. 367-373.

Research output: Contribution to journalArticle

Kent, JW, Mahaney, MC, Comuzzie, AG, Göring, HHH, Almasy, L, Dyer, TD, Cole, SA, MacCluer, JW & Blangero, J 2007, 'Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans', Atherosclerosis, vol. 195, no. 2, pp. 367-373. https://doi.org/10.1016/j.atherosclerosis.2006.10.005
Kent, Jack W. ; Mahaney, Michael C. ; Comuzzie, Anthony G. ; Göring, Harald H H ; Almasy, Laura ; Dyer, Thomas D. ; Cole, Shelley A. ; MacCluer, Jean W. ; Blangero, John. / Quantitative trait locus on Chromosome 19 for circulating levels of intercellular adhesion molecule-1 in Mexican Americans. In: Atherosclerosis. 2007 ; Vol. 195, No. 2. pp. 367-373.
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