Quantitative trait locus mapping using human pedigrees

John Blangero, Jeff T. Williams, Laura Almasy

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

In the past decade phenomenal progress has been made in molecular and statistical genetic methods for localizing quantitative trait loci. Because of these advances, we can anticipate a long period of active genetic research in which the genes influencing human quantitative variability will be mapped and their effects accurately evaluated. Here, we review the current state of the science in statistical genetic methods for quantitative trait linkage analysis. In particular, we detail a variance component-based framework for localizing quantitative trait loci and for accurately estimating their relative effect sizes. Attention is paid to the optimal design of human family studies for localizing genes of small to moderate effect. In addition, methods and strategies are described for dealing with the most important complications of quantitative variation, including the assessment of genotype x environment interaction and epistasis.

Original languageEnglish (US)
Pages (from-to)35-62
Number of pages28
JournalHuman Biology
Volume72
Issue number1
StatePublished - Feb 2000
Externally publishedYes

Fingerprint

Quantitative Trait Loci
Pedigree
pedigree
quantitative trait loci
epistasis
family studies
Genetic Research
gene
quantitative traits
Genes
linkage (genetics)
Molecular Biology
genotype
genes
methodology
Genotype
effect
method

Keywords

  • Linkage analysis
  • Statistical genetics
  • Variance component

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics

Cite this

Blangero, J., Williams, J. T., & Almasy, L. (2000). Quantitative trait locus mapping using human pedigrees. Human Biology, 72(1), 35-62.

Quantitative trait locus mapping using human pedigrees. / Blangero, John; Williams, Jeff T.; Almasy, Laura.

In: Human Biology, Vol. 72, No. 1, 02.2000, p. 35-62.

Research output: Contribution to journalArticle

Blangero, J, Williams, JT & Almasy, L 2000, 'Quantitative trait locus mapping using human pedigrees', Human Biology, vol. 72, no. 1, pp. 35-62.
Blangero J, Williams JT, Almasy L. Quantitative trait locus mapping using human pedigrees. Human Biology. 2000 Feb;72(1):35-62.
Blangero, John ; Williams, Jeff T. ; Almasy, Laura. / Quantitative trait locus mapping using human pedigrees. In: Human Biology. 2000 ; Vol. 72, No. 1. pp. 35-62.
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