Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22.

Guowen Cai, Shelley A. Cole, Raul A. Bastarrachea-Sosa, Jean W. Maccluer, John Blangero, Anthony G. Comuzzie

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

BACKGROUND: Obesity is generally accompanied by increased food intake. OBJECTIVE: We sought to identify the genes influencing variation in dietary macronutrient intakes in Mexican Americans. DESIGN: We conducted a genome-wide scan by using data derived from food-frequency questionnaires in 816 participants from the San Antonio Family Heart Study. Household effect was simultaneously estimated in a variance component model with the use of SOLAR. RESULTS: All dietary intake measures (total calories, proteins, fat, saturated fat, monounsaturated fat, polyunsaturated fat, carbohydrates, and sucrose) were moderately heritable. Household effect was insignificant except on total calories and sucrose. Suggestive evidence of linkage with saturated fat intake was found on chromosome 2p22 near marker D2S1346 [logarithm of odds (LOD) = 2.62]. Intakes of total calories, fat, protein, and monounsaturated fat were also suggestively linked to the same marker. A significant linkage signal on chromosome 2p22 for leptin concentrations and fat mass was localized in this population, so we used leptin or fat mass as a covariate. Multipoint LOD scores for saturated fat dropped to 1.27 and 1.90, respectively, which suggested that this region on chromosome 2p contributes to both saturated fat intake and body adiposity. This chromosomal region contains the proopiomelanocortin gene (POMC). However, 2 polymorphisms in exon 3 of the POMC gene showed no association with saturated fat intake. CONCLUSIONS: The results strengthen the hypothesis that chromosome 2p22 harbors genes that influence a variety of obesity-related phenotypes, including macronutrient intakes.

Original languageEnglish (US)
Pages (from-to)1410-1414
Number of pages5
JournalThe American journal of clinical nutrition
Volume80
Issue number5
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

Quantitative Trait Loci
Human Chromosomes
quantitative trait loci
Fats
chromosomes
fat intake
pro-opiomelanocortin
lipids
leptin
monounsaturated fatty acids
genes
linkage (genetics)
food intake
households
obesity
sucrose
Mexican Americans
Chromosomes
food frequency questionnaires
adiposity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Cai, G., Cole, S. A., Bastarrachea-Sosa, R. A., Maccluer, J. W., Blangero, J., & Comuzzie, A. G. (2004). Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22. The American journal of clinical nutrition, 80(5), 1410-1414.

Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22. / Cai, Guowen; Cole, Shelley A.; Bastarrachea-Sosa, Raul A.; Maccluer, Jean W.; Blangero, John; Comuzzie, Anthony G.

In: The American journal of clinical nutrition, Vol. 80, No. 5, 11.2004, p. 1410-1414.

Research output: Contribution to journalArticle

Cai, G, Cole, SA, Bastarrachea-Sosa, RA, Maccluer, JW, Blangero, J & Comuzzie, AG 2004, 'Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22.', The American journal of clinical nutrition, vol. 80, no. 5, pp. 1410-1414.
Cai G, Cole SA, Bastarrachea-Sosa RA, Maccluer JW, Blangero J, Comuzzie AG. Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22. The American journal of clinical nutrition. 2004 Nov;80(5):1410-1414.
Cai, Guowen ; Cole, Shelley A. ; Bastarrachea-Sosa, Raul A. ; Maccluer, Jean W. ; Blangero, John ; Comuzzie, Anthony G. / Quantitative trait locus determining dietary macronutrient intakes is located on human chromosome 2p22. In: The American journal of clinical nutrition. 2004 ; Vol. 80, No. 5. pp. 1410-1414.
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abstract = "BACKGROUND: Obesity is generally accompanied by increased food intake. OBJECTIVE: We sought to identify the genes influencing variation in dietary macronutrient intakes in Mexican Americans. DESIGN: We conducted a genome-wide scan by using data derived from food-frequency questionnaires in 816 participants from the San Antonio Family Heart Study. Household effect was simultaneously estimated in a variance component model with the use of SOLAR. RESULTS: All dietary intake measures (total calories, proteins, fat, saturated fat, monounsaturated fat, polyunsaturated fat, carbohydrates, and sucrose) were moderately heritable. Household effect was insignificant except on total calories and sucrose. Suggestive evidence of linkage with saturated fat intake was found on chromosome 2p22 near marker D2S1346 [logarithm of odds (LOD) = 2.62]. Intakes of total calories, fat, protein, and monounsaturated fat were also suggestively linked to the same marker. A significant linkage signal on chromosome 2p22 for leptin concentrations and fat mass was localized in this population, so we used leptin or fat mass as a covariate. Multipoint LOD scores for saturated fat dropped to 1.27 and 1.90, respectively, which suggested that this region on chromosome 2p contributes to both saturated fat intake and body adiposity. This chromosomal region contains the proopiomelanocortin gene (POMC). However, 2 polymorphisms in exon 3 of the POMC gene showed no association with saturated fat intake. CONCLUSIONS: The results strengthen the hypothesis that chromosome 2p22 harbors genes that influence a variety of obesity-related phenotypes, including macronutrient intakes.",
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