Quantitative trait locus detection using combined linkage/disequilibrium analysis

Laura Almasy, Jeff T. Williams, Thomas D. Dyer, John Blangero

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


We describe an extension of the variance component linkage method that augments identity-by-descent information from relatives with identity-by- state information from unrelated individuals, exploiting disequilibrium to facilitate fine mapping of quantitative trait loci. An advantage of the combined linkage/disequilibrium test is that it detects association only in the presence of linkage and is not biased by population stratification.

Original languageEnglish (US)
Pages (from-to)S31-S36
JournalGenetic epidemiology
Issue numberSUPPL. 1
StatePublished - 1999
Externally publishedYes


  • Association methods
  • Linkage methods
  • Quantitative trait
  • Statistical genetics

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)


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