Quantitative trait locus detection using combined linkage/disequilibrium analysis

Laura Almasy, Jeff T. Williams, Thomas D. Dyer, John Blangero

    Research output: Contribution to journalArticle

    34 Scopus citations

    Abstract

    We describe an extension of the variance component linkage method that augments identity-by-descent information from relatives with identity-by- state information from unrelated individuals, exploiting disequilibrium to facilitate fine mapping of quantitative trait loci. An advantage of the combined linkage/disequilibrium test is that it detects association only in the presence of linkage and is not biased by population stratification.

    Original languageEnglish (US)
    Pages (from-to)S31-S36
    JournalGenetic epidemiology
    Volume17
    Issue numberSUPPL. 1
    DOIs
    StatePublished - 1999

    Keywords

    • Association methods
    • Linkage methods
    • Quantitative trait
    • Statistical genetics

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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