Quantitative genetics of dehydroepiandrosterone sulfate and its relation to possible cardiovascular disease risk factors in mexican americans

C. E. Jaquish, J. Blangero, S. M. Haffner, M. P. Stern, J. W. Maccluer

    Research output: Contribution to journalArticle

    21 Scopus citations

    Abstract

    Dehydroepiandrosterone sulfate (DHEAS) is an adrenal steroid which has been inversely associated with development of atherosclerosis. We estimated heritability of serum DHEAS levels in 564 related Mexican Americans. We found a significant heritability for DHEAS (h2 = 0.39, p < 0.001). Measures of alcohol consumption, reproductive status, body composition, and HDL3 levels showed significant relationships with serum DHEAS levels. Sex and age were significantly associated with the mean, but not the genetic variance, of DHEAS levels. The results of this study demonstrate a significant genetic influence on steroid concentration and help to quantify the factors contributing to cardiovascular disease risk in Mexican Americans.

    Original languageEnglish (US)
    Pages (from-to)301-309
    Number of pages9
    JournalHuman Heredity
    Volume46
    Issue number6
    DOIs
    StatePublished - Jan 1 1996

    Keywords

    • Adrenal steroids
    • Dehydroepiandrosterone sulfate
    • High density
    • Lipoproteins

    ASJC Scopus subject areas

    • Genetics
    • Genetics(clinical)

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