Quantitative dynamic MRI (QdMRI) volumetric analysis of pediatric patients with thoracic insufficiency syndrome

Yubing Tong, Jayaram K. Udupa, E. Paul Wileyto, Caiyun Wu, Joseph M. McDonough, Anthony Capraro, Oscar H. Mayer, Drew A. Torigian, Robert M. Campbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The lack of standardizable objective diagnostic measurement techniques is a major hurdle in the assessment and treatment of pediatric patients with thoracic insufficiency syndrome (TIS). The aim of this paper is to explore quantitative dynamic MRI (QdMRI) volumetric parameters derived from thoracic dMRI in pediatric patients with TIS and the relationships between dMRI parameters and clinical measurements. 25 TIS patients treated with vertical expandable prosthetic titanium rib (VEPTR) surgery are included in this retrospective study. Left and right lungs at endinspiration and end-expiration are segmented from constructed 4D dMRI images. Lung volumes and excursion (or tidal) volumes of the left/right chest wall and hemi-diaphragms are computed. Commonly used clinical parameters include thoracic and lumbar Cobb angles and respiratory measurements from pulmonary function testing (PFT). 200 3D lungs in total (left & right, pre-operative & post-operative, end-inspiration & end-expiration) are segmented for analysis. Our analysis indicates that change of resting breathing rate (RR) following surgery is negatively correlated with that of QdMRI parameters. Chest wall tidal volumes and hemi-diaphragm tidal volumes increase significantly following surgery. Clinical parameter RR reduced after surgical treatment with P values around 0.06 but no significant differences were found on other clinical parameters. The significant increase in post-operative tidal volumes suggests a treatment-related improvement in lung capacity. The reduction of RR following surgery shows that breathing function is improved. The QdMRI parameters may offer an objective marker set for studying TIS, which is currently lacking.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2018
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
EditorsBarjor Gimi, Andrzej Krol
PublisherSPIE
ISBN (Electronic)9781510616455
DOIs
StatePublished - 2018
Externally publishedYes
EventMedical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging - Houston, United States
Duration: Feb 11 2018Feb 13 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10578
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging
Country/TerritoryUnited States
CityHouston
Period2/11/182/13/18

Keywords

  • lung
  • pediatric thoracic function
  • Quantitative dynamic MRI (QdMRI)
  • thoracic insufficiency syndrome (TIS)
  • tidal volume

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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