Quantification of left-ventricular regional dyssynergy by radionuclide angiography

M. R. Starling, R. A. Walsh, J. C. Lasher, J. L. Lancaster, R. Blumhardt

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Abstract

To determine whether variables obtained from Fourier analysis of gated equilibrium radionuclide angiographic (RNA) images can detect and quantify changes in left-ventricular (LV) regional wall motion induced by transient ischemia, 11 chronically instrumented dogs were simultaneously studied with hemodynamic measurements and RNA during control, left circumflex (LCx) coronary artery occlusion, and postocclusion conditions. The dogs were preinstrumented with aortic and LV catheters, electromagnetic aortic and LCx coronary artery flow probes, high-fidelity LV micromanometers, LCx coronary artery occluders, and 4-mm ultrasonic transverse LV diameter and 2-mm regional LV segment crystal pairs. Radionuclide LV regional phase and amplitude variables were calculated for each condition. The absolute changes in LCx region RNA mean, median, and standard deviation of mean phase correlated with the percent changes in LCx segment crystal fractional shortening (r=-0.71, -0.64, and-0.51, respectively; all p≤0.01). Similarly, the absolute changes and percent changes in LCx region RNA mean amplitude per pixel correlated with the percent changes in LCx segment crystal fractional shortening (r = 0.89 and 0.94, respectively; both p<0.001). When these LCx region RNA phase variables were subgrouped according to mild or severe depression or augmentation in LCx segment crystal fractional shortening, progressive differences were observed between the average values for these subgroups (p<0.05 to p<0.001). These data, therefore, suggest that these regional RNA phase variables may be able to detect and quantify alterations in LV contraction patterns due to transient ischemia.

Original languageEnglish (US)
Pages (from-to)1725-1735
Number of pages11
JournalJournal of Nuclear Medicine
Volume28
Issue number11
Publication statusPublished - Dec 1 1987

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Starling, M. R., Walsh, R. A., Lasher, J. C., Lancaster, J. L., & Blumhardt, R. (1987). Quantification of left-ventricular regional dyssynergy by radionuclide angiography. Journal of Nuclear Medicine, 28(11), 1725-1735.