TY - JOUR
T1 - Quality of life after lacunar stroke
T2 - The secondary prevention of small subcortical strokes study
AU - Dhamoon, Mandip S.
AU - McClure, Leslie A.
AU - White, Carole L.
AU - Lau, Helena
AU - Benavente, Oscar
AU - Elkind, Mitchell S.V.
PY - 2014
Y1 - 2014
N2 - We sought to describe the course and predictors of quality of life (QOL) after lacunar stroke. We hypothesized that there is a decline in QOL after recovery from lacunar stroke. Methods: The Secondary Prevention of Small Subcortical Strokes is a clinical trial in lacunar stroke patients with annual assessments of QOL with the stroke-specific QOL score. The overall score was used and analyzed as a continuous variable (range 0-5). We fit linear mixed models to assess the trend in QOL over time, assuming linearity of time, and adjusted for demographics, medical risk factors, cognitive factors, and functional status in univariable and multivariable models. Results: Among 2870 participants, mean age was 63.4 years (SD 10.7), 63% were men, 51% White, 32% Hispanic, 36% had college education, 36% had diabetes, 89% had hypertension, and 10% had prior stroke. Mean poststroke Barthel Index (BI) score was 95.4 (assessed on average 6 months after stroke). In the final multivariable model, there was an average increase in QOL of.6% per year, and factors associated with decline in QOL over time included age (-.0003 per year, P <.0001), any college education (-.0013 per year,.01), prior stroke (-.004 per year, P <.0001), and BI (-.0002 per year, P <.0001). Conclusions: In this clinical trial of lacunar stroke patients, there was a slight annual increase in QOL overall, and age, level of education, and prior stroke were associated with changes in QOL over time. Multiple strokes may cause decline in QOL over time in the absence of recurrent events.
AB - We sought to describe the course and predictors of quality of life (QOL) after lacunar stroke. We hypothesized that there is a decline in QOL after recovery from lacunar stroke. Methods: The Secondary Prevention of Small Subcortical Strokes is a clinical trial in lacunar stroke patients with annual assessments of QOL with the stroke-specific QOL score. The overall score was used and analyzed as a continuous variable (range 0-5). We fit linear mixed models to assess the trend in QOL over time, assuming linearity of time, and adjusted for demographics, medical risk factors, cognitive factors, and functional status in univariable and multivariable models. Results: Among 2870 participants, mean age was 63.4 years (SD 10.7), 63% were men, 51% White, 32% Hispanic, 36% had college education, 36% had diabetes, 89% had hypertension, and 10% had prior stroke. Mean poststroke Barthel Index (BI) score was 95.4 (assessed on average 6 months after stroke). In the final multivariable model, there was an average increase in QOL of.6% per year, and factors associated with decline in QOL over time included age (-.0003 per year, P <.0001), any college education (-.0013 per year,.01), prior stroke (-.004 per year, P <.0001), and BI (-.0002 per year, P <.0001). Conclusions: In this clinical trial of lacunar stroke patients, there was a slight annual increase in QOL overall, and age, level of education, and prior stroke were associated with changes in QOL over time. Multiple strokes may cause decline in QOL over time in the absence of recurrent events.
KW - Lacunar stroke
KW - disability
KW - quality of life
KW - recovery
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U2 - 10.1016/j.jstrokecerebrovasdis.2013.09.029
DO - 10.1016/j.jstrokecerebrovasdis.2013.09.029
M3 - Article
C2 - 24177006
AN - SCOPUS:84901307347
SN - 1052-3057
VL - 23
SP - 1131
EP - 1137
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
IS - 5
ER -