PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in rats

Lance R. McMahon, Paul J. Wellman

Research output: Contribution to journalArticle

154 Scopus citations

Abstract

Intracerebroventricular infusion of glucagon-like peptide-l-(7- 36) amide (GLP-1) reduces feeding in rats, an effect that could be localized to the hypothalamic paraventricular nucleus (PVN). Intracerebroventricular GLP- 1, however, may also induce conditioned taste aversion (CTA), thereby putting into question the specificity of the action of GLP-1 on feeding. The present experiments evaluated the action of PVN GLP-1 (0, 100, or 200 ng) on induction of CTA, on locomotion, and finally, on feeding and drinking in rats. PVN infusion of GLP-1 (100 or 200 ng) did not support the induction of CTA and did not reliably alter locomotion, but did suppress feeding and drinking. The present study suggests that GLP-1 infusions into the PVN reduce food and water intake without producing illness or disrupting locomotor behavior. These data, in conjunction with reports of increased feeding following antagonism of central GLP-1 receptors, support the notion that endogenous GLP-1, perhaps within the PVN, functions to suppress feeding in the rat.

Original languageEnglish (US)
Pages (from-to)R23-R29
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume274
Issue number1 43-1
StatePublished - Jan 1 1998

Keywords

  • Food intake
  • Gut-brain interactions
  • Paraventricular nucleus
  • Peptides
  • Saccharin
  • Satiety

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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