Purine inhibition of [3H]-γ-aminobutyric acid receptor binding to rat brain membranes

Maharaj K. Ticku, Troie Burch

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Several purines, including inosine and hypoxanthine, inhibit the binding of [3H]-γ-amino-butyric acid (GABA) and [3H]diazepam to freeze-thawed and extensively washed rat brain membranes. While purines have been reported to inhibit diazepam binding competitively, their interactions with GABA receptors in both mitochondrial and mitochondrial plus microsomal fractions are noncompetitive. The possibility that purines may bind at one site and affect the GABA receptor-ionophore-benzodi-azepine complex is discussed.

Original languageEnglish (US)
Pages (from-to)1217-1220
Number of pages4
JournalBiochemical Pharmacology
Volume29
Issue number9
DOIs
StatePublished - May 1 1980

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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