Pulp Injury and Changing Trends in Treatment

Kenneth M. Hargreaves, Anibal Diogenes, Fabricio B. Teixeira

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


In contrast to the high long-term survival rates (>. 93%) of conventional endodontic treatment applied to mature permanent teeth, the treatment of the immature permanent tooth with a necrotic root canal system and apical periodontitis is challenging, due in part to incomplete root development leading to thin dentinal walls and reduced overall length. Conventional apexification procedures treat apical periodontitis in immature teeth, but the cases often have a poor prognosis due to weak root structures. Recent studies have employed a tissue engineering approach designed to regenerate a pulp-like tissue, resulting in continued radiographic root development, healing of apical periodontitis, and improved overall tooth survival. This chapter reviews the biological basis of regenerative endodontics and provides a perspective to interpret ongoing research in this dynamic area.

Original languageEnglish (US)
Title of host publicationStem Cell Biology and Tissue Engineering in Dental Sciences
PublisherElsevier Inc.
Number of pages8
ISBN (Electronic)9780123977786
ISBN (Print)9780123971579
StatePublished - 2015


  • Pulpal revascularization
  • Regenerative endodontics
  • Stem cells
  • Tissue engineering

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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