Pulmonary oxygen uptake and heart rate kinetics during the six-minute walk test in transplant recipients

Corey R. Tomczak, Darren E.R. Warburton, Kenneth J. Riess, Nicholas G. Jendzjowsky, Ben T. Esch, Yuanyuan Liang, Robert G. Haennel, Mark J. Haykowsky

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

BACKGROUND. The effect of organ transplantation on arterial compliance, pulmonary oxygen uptake (&OV0312;O2p) and heart rate kinetics during the 6-minute walk test (6-MWT) remains unknown. METHODS. Twenty-two thoracic (heart and/or lung) organ transplant recipients (TOTR, 51±12 years) and 30 abdominal (kidney, kidney-pancreas, or liver) organ transplant recipients (AOTR, 46±11 years) from the 2006 Canadian Transplant Games, and 37 healthy controls (HC) completed a 6-MWT. &OV0312;O2p, heart rate kinetics, and arterial compliance were determined. RESULTS. The 6-MWT distance and highest &OV0312;O2p were significantly lower in TOTR and AOTR versus HC. The highest 6-MWT heart rate was lower in TOTR (11%) and AOTR (13%) versus HC. &OV0312;O2p kinetics were slower in TOTR (52±11 sec, P≤0.001) and AOTR (45±24 sec, P≤0.001) versus HC (28±9 sec). Heart rate kinetics were slower in TOTR (100±49 sec) versus AOTR (41±21 sec, P≤0.001) and HC (34±21 sec, P≤0.001), but not between AOTR and HC. Small and large artery compliance were 26% (P=0.007) and 19% (P=0.004) lower, respectively, in TOTR versus HC. Large artery compliance was 14% lower in TOTR versus AOTR (P=0.017). 6-MWT distance was significantly related to &OV0312;O2p kinetics (r=-0.35) and the highest 6-MWT &OV0312;O2p (r=0.72). CONCLUSIONS. TOTR and AOTR have abnormal &OV0312;O2p kinetics, which is secondary to prolonged heart rate kinetics and impaired vascular function in TOTR, but not AOTR.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalTransplantation
Volume85
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Keywords

  • 6-minute walk test
  • Arterial compliance
  • Organ transplantation
  • Pulmonary oxygen uptake kinetics

ASJC Scopus subject areas

  • Transplantation

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    Tomczak, C. R., Warburton, D. E. R., Riess, K. J., Jendzjowsky, N. G., Esch, B. T., Liang, Y., Haennel, R. G., & Haykowsky, M. J. (2008). Pulmonary oxygen uptake and heart rate kinetics during the six-minute walk test in transplant recipients. Transplantation, 85(1), 29-35. https://doi.org/10.1097/01.tp.0000296056.00863.f0