Pulmonary intravascular leukocyte sequestration. A potential mechanism of lung injury

E. H. Wittels, J. J. Coalson, M. H. Welch, C. A. Guenter

Research output: Chapter in Book/Report/Conference proceedingChapter

25 Citations (Scopus)

Abstract

Emphysema associated with alpha1 antitrypsin deficiency may be a result of uninhibited action of proteolytic enzymes on lung tissues. The panacinar distribution and predilection for lower lung zones suggest that the injurious components may be distributed primarily through the pulmonary circulation. The observation that leukocyte lysosomes contain certain neutral proteases that are elastolytic emphasized these as a possible source of proteolytic enzymes. These studies demonstrate a model for repetitive pulmonary vascular leukocyte sequestration that may be associated with early widespread alveolar disruption.

Original languageEnglish (US)
Title of host publicationAMER.REV.RESP.DIS.
Pages502-509
Number of pages8
Volume109
Edition5
StatePublished - 1974
Externally publishedYes

Fingerprint

Lung Injury
Leukocytes
Peptide Hydrolases
Lung
Pulmonary Circulation
Emphysema
Lysosomes
Blood Vessels

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wittels, E. H., Coalson, J. J., Welch, M. H., & Guenter, C. A. (1974). Pulmonary intravascular leukocyte sequestration. A potential mechanism of lung injury. In AMER.REV.RESP.DIS. (5 ed., Vol. 109, pp. 502-509)

Pulmonary intravascular leukocyte sequestration. A potential mechanism of lung injury. / Wittels, E. H.; Coalson, J. J.; Welch, M. H.; Guenter, C. A.

AMER.REV.RESP.DIS.. Vol. 109 5. ed. 1974. p. 502-509.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wittels, EH, Coalson, JJ, Welch, MH & Guenter, CA 1974, Pulmonary intravascular leukocyte sequestration. A potential mechanism of lung injury. in AMER.REV.RESP.DIS.. 5 edn, vol. 109, pp. 502-509.
Wittels EH, Coalson JJ, Welch MH, Guenter CA. Pulmonary intravascular leukocyte sequestration. A potential mechanism of lung injury. In AMER.REV.RESP.DIS.. 5 ed. Vol. 109. 1974. p. 502-509
Wittels, E. H. ; Coalson, J. J. ; Welch, M. H. ; Guenter, C. A. / Pulmonary intravascular leukocyte sequestration. A potential mechanism of lung injury. AMER.REV.RESP.DIS.. Vol. 109 5. ed. 1974. pp. 502-509
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