Pulmonary interstitial emphysema in the premature baboon with hyaline membrane disease

N. B. Ackerman, J. J. Coalson, T. J. Kuehl, R. Stoddard, L. Minnick, M. B. Escobedo, D. M. Null, J. L. Robotham, R. deLemos

Research output: Contribution to journalArticle

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Abstract

During experiments designed to develop an appropriate ventilatory strategy for high-frequency ventilation (HFV) in the premature baboon with hyaline membrane disease (HMD), we observed the development of pulmonary interstitial emphysema (PIE). Four study groups of 5 animals each received positive-pressure ventilation and positive end-expiratory pressure (PPV/PEEP) or HFV and 1 of 3 sighing techniques. Pathologically, all animals ventilated with PPV/PEEP or HFV with a carefully controlled intermittent sigh developed dilatation of the distal conduction airway and alveolar duct, with poorly expanded pulmonary saccules. The imposition of a sigh with inappropriate timing or excessive volume ruptured the dilated airway walls and caused interstitial air to accumulate. This was evident from the location of striking dilation of the distal airways and pseudocysts in areas of atelectasis. Thus, early in the course of HMD when saccular aeration is minimal, the pathogenesis of PIE is related to airway rather than alveolar rupture.

Original languageEnglish (US)
Pages (from-to)512-516
Number of pages5
JournalCritical Care Medicine
Volume12
Issue number6
StatePublished - 1984
Externally publishedYes

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Hyaline Membrane Disease
Pulmonary Emphysema
Positive-Pressure Respiration
Papio
High-Frequency Ventilation
Dilatation
Saccule and Utricle
Pulmonary Atelectasis
Rupture
Air
Lung

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Ackerman, N. B., Coalson, J. J., Kuehl, T. J., Stoddard, R., Minnick, L., Escobedo, M. B., ... deLemos, R. (1984). Pulmonary interstitial emphysema in the premature baboon with hyaline membrane disease. Critical Care Medicine, 12(6), 512-516.

Pulmonary interstitial emphysema in the premature baboon with hyaline membrane disease. / Ackerman, N. B.; Coalson, J. J.; Kuehl, T. J.; Stoddard, R.; Minnick, L.; Escobedo, M. B.; Null, D. M.; Robotham, J. L.; deLemos, R.

In: Critical Care Medicine, Vol. 12, No. 6, 1984, p. 512-516.

Research output: Contribution to journalArticle

Ackerman, NB, Coalson, JJ, Kuehl, TJ, Stoddard, R, Minnick, L, Escobedo, MB, Null, DM, Robotham, JL & deLemos, R 1984, 'Pulmonary interstitial emphysema in the premature baboon with hyaline membrane disease', Critical Care Medicine, vol. 12, no. 6, pp. 512-516.
Ackerman NB, Coalson JJ, Kuehl TJ, Stoddard R, Minnick L, Escobedo MB et al. Pulmonary interstitial emphysema in the premature baboon with hyaline membrane disease. Critical Care Medicine. 1984;12(6):512-516.
Ackerman, N. B. ; Coalson, J. J. ; Kuehl, T. J. ; Stoddard, R. ; Minnick, L. ; Escobedo, M. B. ; Null, D. M. ; Robotham, J. L. ; deLemos, R. / Pulmonary interstitial emphysema in the premature baboon with hyaline membrane disease. In: Critical Care Medicine. 1984 ; Vol. 12, No. 6. pp. 512-516.
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