Pulmonary hypertension, right ventricular failure, and kidney: Different from left ventricular failure?

Robert W. Schrier, Shweta Bansal

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

In this article, the pathophysiology of left ventricular failure is reviewed. By contrast, the paucity of information about pulmonary arterial hypertension and right ventricular failure is acknowledged. The potential mechanisms whereby renal sodium and water retention in right ventricular failure secondary to pulmonary arterial hypertension can occur, despite normal left ventricular function, are discussed. With right ventricular failure as the primary cause of death in patients with pulmonary hypertension, more information about the mechanisms of renal sodium and water retention in these patients is direly needed. Specifically, studies to examine the activation of the neurohumoral axis at various stages of pulmonary arterial hypertension and right ventricular failure, including inhibition of mineralocorticoid and V2 vasopressin receptors, are indicated.

Original languageEnglish (US)
Pages (from-to)1232-1237
Number of pages6
JournalClinical Journal of the American Society of Nephrology
Volume3
Issue number5
DOIs
StatePublished - Sep 2008
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

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