Abstract
Bleomycin was administered intrabronchially to four baboons in doses of 1 mg/kg for four consecutive weeks. At necropsy 6 months later, the lesions produced differed markedly from those resulting from parenteral administration of bleomycin and consisted of diffuse foci of inflammation and fibrosis of the lung parenchyma associated with small airway lesions. Airway lesions were found in respiratory bronchioles and consisted of bronchiolar wall inflammation, hyper-plasia of smooth muscle, and epithelial bronchiolization of adjacent alveolated structures. Many bronchioles were obliterated by the fibrotic process. Physiologically, these animals demonstrated findings of both lung fibrosis and obstruction of small airways. Biochemical measurements confirmed the histologic appearance of increased lung collagen in three of four animals. These findings indicate that obstruction of small airways by processes which cause lung fibrosis may be separable physiologically from processes which affect only the lung parenchyma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 91-108 |
| Number of pages | 18 |
| Journal | Experimental Lung Research |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1982 |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Molecular Biology
- Clinical Biochemistry
Cite this
Pulmonary fibrosis with small-airway disease : A model in nonhuman primates. / Collins, James F.; Orozco, Carlos R.; McCullough, Bruce; Coalson, Jacqueline J.; Johanson, W. G.
In: Experimental Lung Research, Vol. 3, No. 2, 1982, p. 91-108.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pulmonary fibrosis with small-airway disease
T2 - A model in nonhuman primates
AU - Collins, James F.
AU - Orozco, Carlos R.
AU - McCullough, Bruce
AU - Coalson, Jacqueline J.
AU - Johanson, W. G.
PY - 1982
Y1 - 1982
N2 - Bleomycin was administered intrabronchially to four baboons in doses of 1 mg/kg for four consecutive weeks. At necropsy 6 months later, the lesions produced differed markedly from those resulting from parenteral administration of bleomycin and consisted of diffuse foci of inflammation and fibrosis of the lung parenchyma associated with small airway lesions. Airway lesions were found in respiratory bronchioles and consisted of bronchiolar wall inflammation, hyper-plasia of smooth muscle, and epithelial bronchiolization of adjacent alveolated structures. Many bronchioles were obliterated by the fibrotic process. Physiologically, these animals demonstrated findings of both lung fibrosis and obstruction of small airways. Biochemical measurements confirmed the histologic appearance of increased lung collagen in three of four animals. These findings indicate that obstruction of small airways by processes which cause lung fibrosis may be separable physiologically from processes which affect only the lung parenchyma.
AB - Bleomycin was administered intrabronchially to four baboons in doses of 1 mg/kg for four consecutive weeks. At necropsy 6 months later, the lesions produced differed markedly from those resulting from parenteral administration of bleomycin and consisted of diffuse foci of inflammation and fibrosis of the lung parenchyma associated with small airway lesions. Airway lesions were found in respiratory bronchioles and consisted of bronchiolar wall inflammation, hyper-plasia of smooth muscle, and epithelial bronchiolization of adjacent alveolated structures. Many bronchioles were obliterated by the fibrotic process. Physiologically, these animals demonstrated findings of both lung fibrosis and obstruction of small airways. Biochemical measurements confirmed the histologic appearance of increased lung collagen in three of four animals. These findings indicate that obstruction of small airways by processes which cause lung fibrosis may be separable physiologically from processes which affect only the lung parenchyma.
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U2 - 10.3109/01902148209063285
DO - 10.3109/01902148209063285
M3 - Article
C2 - 6179774
AN - SCOPUS:0020131724
VL - 3
SP - 91
EP - 108
JO - Experimental Lung Research
JF - Experimental Lung Research
SN - 0190-2148
IS - 2
ER -